Detailed information for compound 1552532

Basic information

Technical information
  • TDR Targets ID: 1552532
  • Name: N-[(2-chlorophenyl)methyl]-4-oxo-4-(6H-pyrido [2,3-b][1,4]benzoxazepin-5-yl)butanamide
  • MW: 421.876 | Formula: C23H20ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 2.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1Cl)CCC(=O)N1Cc2ccccc2Oc2c1cccn2
  • InChi: 1S/C23H20ClN3O3/c24-18-8-3-1-6-16(18)14-26-21(28)11-12-22(29)27-15-17-7-2-4-10-20(17)30-23-19(27)9-5-13-25-23/h1-10,13H,11-12,14-15H2,(H,26,28)
  • InChiKey: CDIGBQXKYCWLNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chlorobenzyl)-4-keto-4-(6H-pyrido[2,3-b][1,4]benzoxazepin-5-yl)butyramide
  • E986-0032
  • NCGC00127631-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0054 1 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0054 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0451 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.6182 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Schistosoma mansoni shc transforming protein 0.0041 0.677 0.677
Echinococcus granulosus ephrin type A receptor 4 A 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0054 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0014 0.0451 0.0451
Giardia lamblia Protein 21.1 0.0014 0.0451 0.5
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Brugia malayi SRC-1 0.0054 1 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Schistosoma mansoni growth factor receptor-bound protein 0.0041 0.677 0.677
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Echinococcus multilocularis NCK adaptor protein 0.0041 0.677 0.677
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.677 0.677
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Echinococcus multilocularis insulin receptor 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0041 0.677 0.6617
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase HCK 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Toxoplasma gondii STE kinase 0.0014 0.0451 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0014 0.0451 0.0451
Echinococcus multilocularis natriuretic peptide receptor 1 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0014 0.0451 0.0451
Brugia malayi tRNA modification GTPase TrmE family protein 0.0041 0.677 0.677
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0041 0.677 0.677
Brugia malayi hypothetical protein 0.0014 0.0451 0.0451
Toxoplasma gondii protein kinase 0.0014 0.0451 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0054 1 1
Leishmania major hypothetical protein, conserved 0.0014 0.0451 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Schistosoma mansoni ephrin receptor 0.0014 0.0451 0.0451
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0014 0.0451 0.0451
Echinococcus multilocularis SH2 motif 0.0041 0.677 0.677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Brugia malayi Guanylyl cyclase protein 23 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Echinococcus multilocularis SHC transforming protein 3 0.0041 0.677 0.677
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.7694 0.7694
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.6182 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 1 1
Echinococcus granulosus NCK adaptor protein 0.0041 0.677 0.677
Schistosoma mansoni nck2/grb4 0.0041 0.677 0.677
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0451 0.0451
Echinococcus granulosus hypothetical protein 0.0041 0.677 0.677
Schistosoma mansoni ephrin receptor 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0041 0.677 0.677
Onchocerca volvulus 0.0041 0.677 0.6617
Echinococcus granulosus SH2 domain containing protein 7 0.0041 0.677 0.677
Echinococcus granulosus suppressor of cytokine signaling 7 0.0041 0.677 0.677
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase ABL1 0.0054 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni signal transduction protein lnk-related 0.0041 0.677 0.677
Leishmania major protein kinase, putative 0.0014 0.0451 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0041 0.677 0.677
Trypanosoma brucei protein kinase, putative 0.0014 0.0451 0.5
Onchocerca volvulus 0.0054 1 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus c src tyrosine kinase 0.0054 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0054 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0054 1 1
Schistosoma mansoni hypothetical protein 0.0014 0.0451 0.0451
Brugia malayi protein-tyrosine kinase 0.0054 1 1
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Toxoplasma gondii protein kinase domain-containing protein 0.0014 0.0451 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0014 0.0451 0.0451
Echinococcus granulosus protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus kinase suppressor of Ras 1 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus multilocularis N chimaerin 0.0041 0.677 0.677
Echinococcus multilocularis activin receptor type 0.0014 0.0451 0.0451
Loa Loa (eye worm) protein kinase domain-containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase Src42A 0.0054 1 1
Echinococcus multilocularis SH2 motif 0.0041 0.677 0.677
Echinococcus multilocularis SH2 domain containing protein 7 0.0041 0.677 0.677
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0054 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Echinococcus granulosus natriuretic peptide receptor 1 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/ABL protein kinase 0.0054 1 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0041 0.677 0.677
Echinococcus granulosus tyrosine kinase 0.0054 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0041 0.677 0.677
Echinococcus granulosus tyrosine protein kinase pr2 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus activated cdc42 kinase 1 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0041 0.677 0.677
Echinococcus granulosus raf serine:threonine protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0041 0.677 0.6617
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0054 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.677 0.677
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0451 0.0451
Brugia malayi Variant SH3 domain containing protein 0.0041 0.677 0.677
Loa Loa (eye worm) TK/INSR protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Abl 0.0054 1 1
Brugia malayi hypothetical protein 0.0014 0.0451 0.0451
Schistosoma mansoni tensin-related 0.0041 0.677 0.677
Schistosoma mansoni suppressor of cytokine signaling 0.0041 0.677 0.677
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.677 0.677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Echinococcus granulosus insulin receptor 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus multilocularis protein KINase family member (kin 25) 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0041 0.677 0.6617
Echinococcus multilocularis ephrin type A receptor 4 A 0.0014 0.0451 0.0451
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0451 0.0451
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Onchocerca volvulus 0.0041 0.677 0.6617
Plasmodium falciparum tyrosine kinase-like protein 0.0014 0.0451 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0054 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0014 0.0451 0.0451
Schistosoma mansoni suppressor of cytokine signaling 0.0041 0.677 0.677
Brugia malayi Tensin 0.0041 0.677 0.677
Onchocerca volvulus 0.0041 0.677 0.6617
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0041 0.677 0.677
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Echinococcus multilocularis receptor type guanylyl cyclase 0.0014 0.0451 0.0451
Echinococcus multilocularis signal transduction protein lnk realted 0.0041 0.677 0.677
Brugia malayi cytokine inducible SH2-containing protein 5 0.0041 0.677 0.677
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.6813 0.6813
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus growth factor receptor bound protein 2 0.0041 0.677 0.677
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0451 0.0451
Echinococcus multilocularis c src tyrosine kinase 0.0054 1 1
Brugia malayi SH2 domain containing protein 0.0054 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0014 0.0451 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Echinococcus granulosus protein tyrosine kinase 0.0014 0.0451 0.0451
Entamoeba histolytica protein kinase, putative 0.0041 0.677 0.6617
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Brugia malayi hypothetical protein 0.0054 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase shark 0.0054 1 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0041 0.677 0.677
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Loa Loa (eye worm) serine/threonine protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus epidermal growth factor receptor 0.0014 0.0451 0.0451
Loa Loa (eye worm) SRC-1 0.0054 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0054 1 1
Plasmodium falciparum protein kinase, putative 0.0014 0.0451 0.5
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0041 0.677 0.677
Echinococcus granulosus activin receptor type 0.0014 0.0451 0.0451
Echinococcus multilocularis protein tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tensin 0.0041 0.677 0.677
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Brugia malayi STAT protein, DNA binding domain containing protein 0.0041 0.677 0.677
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.6813 0.6813
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0041 0.677 0.677
Loa Loa (eye worm) SH2 domain-containing protein 0.0041 0.677 0.677
Schistosoma mansoni tensin 0.0041 0.677 0.677
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0014 0.0451 0.0451
Trypanosoma brucei Pseudokinase, putative 0.0014 0.0451 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus expressed conserved protein 0.0041 0.677 0.677
Brugia malayi Protein kinase domain containing protein 0.0054 1 1
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Schistosoma mansoni growth factor receptor-bound protein 0.0041 0.677 0.677
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0054 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni GTPase activating protein 0.0041 0.677 0.677
Schistosoma mansoni tensin 0.0041 0.677 0.677
Brugia malayi Raf kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/DDR protein kinase 0.0014 0.0451 0.0451
Giardia lamblia Kinase 0.0014 0.0451 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0451 0.0451
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0054 1 1
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 1 1
Echinococcus multilocularis tyrosine protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0041 0.677 0.677
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.6813 0.6813
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0054 1 1
Trypanosoma cruzi protein kinase, putative 0.0014 0.0451 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0054 1 1
Plasmodium falciparum protein kinase, putative 0.0014 0.0451 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0014 0.0451 0.0451
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0014 0.0451 0.0451
Echinococcus granulosus epidermal growth factor receptor 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Brugia malayi bone morphogenetic protein type 1 receptor 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0054 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0054 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0041 0.677 0.677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0014 0.0451 0.0451
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0014 0.0451 0.0451
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.677 0.677
Echinococcus multilocularis epidermal growth factor receptor 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0054 1 1
Echinococcus multilocularis SH2 motif 0.0041 0.677 0.677
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0014 0.0451 0.0451
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.6813 0.6813
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Echinococcus multilocularis tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 1 1
Brugia malayi SH2 domain containing protein 0.0041 0.677 0.677
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0041 0.677 0.677
Echinococcus multilocularis protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0041 0.677 0.677
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.677 0.677
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/RYK protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0054 1 1
Echinococcus granulosus SH2 motif 0.0041 0.677 0.677
Brugia malayi Variant SH3 domain containing protein 0.0041 0.677 0.677
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Schistosoma mansoni tensin-related 0.0041 0.677 0.677
Echinococcus multilocularis integrin linked protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Brugia malayi Tyrosine-protein kinase PR2 0.0014 0.0451 0.0451
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0041 0.677 0.6617
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni tensin 0.0041 0.677 0.677
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0041 0.677 0.677
Loa Loa (eye worm) hypothetical protein 0.0035 0.5546 0.5546
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0041 0.677 0.677
Trypanosoma brucei Flagellum attachment zone protein 20 0.0014 0.0451 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus receptor type guanylyl cyclase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FAK protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni protein tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0054 1 1
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.677 0.677
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0041 0.677 0.677
Loa Loa (eye worm) TK/Met protein kinase 0.0014 0.0451 0.0451
Brugia malayi ephrin receptor 1 precursor 0.0014 0.0451 0.0451
Echinococcus granulosus activated cdc42 kinase 1 0.0014 0.0451 0.0451
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0054 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0014 0.0451 0.0451
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0041 0.677 0.6617
Echinococcus granulosus tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/ROR protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0041 0.677 0.677
Echinococcus multilocularis growth factor receptor bound protein 2 0.0041 0.677 0.677
Brugia malayi Sex muscle abnormal protein 5 0.0041 0.677 0.677
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0014 0.0451 0.0451
Brugia malayi Variant SH3 domain containing protein 0.0041 0.677 0.677
Echinococcus multilocularis FL cytokine receptor 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Brugia malayi C-terminal src kinase protein 1 0.0014 0.0451 0.0451
Schistosoma mansoni adapter molecule crk 0.0041 0.677 0.677
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0014 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0041 0.677 0.677
Echinococcus multilocularis protein kinase 0.0014 0.0451 0.0451
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0451 0.5
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0041 0.677 0.677
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus suppressor of cytokine signaling 6 0.0041 0.677 0.677
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0054 1 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0041 0.677 0.677
Echinococcus multilocularis kinase suppressor of Ras 1 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Brugia malayi hypothetical protein 0.0041 0.677 0.677
Echinococcus multilocularis tyrosine kinase 0.0054 1 1
Entamoeba histolytica SH2 domain containing protein 0.0041 0.677 0.6617
Giardia lamblia Kinase, NEK 0.0014 0.0451 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0054 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0041 0.677 0.6617
Loa Loa (eye worm) TK/EGFR protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0054 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0014 0.0451 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Loa Loa (eye worm) STAT protein 0.0041 0.677 0.677
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus integrin linked protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/ALK protein kinase 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Brugia malayi Furin-like cysteine rich region family protein 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Echinococcus multilocularis tensin 0.0041 0.677 0.677
Loa Loa (eye worm) TK/EPH protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Brugia malayi Variant SH3 domain containing protein 0.0041 0.677 0.677
Brugia malayi Tyrosine-protein kinase abl-1 0.0054 1 1
Schistosoma mansoni tyrosine kinase 0.0054 1 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0054 1 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0014 0.0451 0.0451
Echinococcus granulosus signal transduction protein lnk realted 0.0041 0.677 0.677
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0041 0.677 0.677
Echinococcus granulosus tyrosine kinase 0.0054 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Brugia malayi RhoGAP domain containing protein 0.0041 0.677 0.677
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0014 0.0451 0.0451
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0451 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0451 0.0451
Echinococcus multilocularis heat shock protein 70 0.0014 0.0451 0.0451
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.7694 0.7694
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0041 0.677 0.677
Echinococcus multilocularis transfer RNA-Thr 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0054 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0451 0.0451
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0451 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0014 0.0451 0.5
Echinococcus granulosus N chimaerin 0.0041 0.677 0.677
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Leishmania major protein kinase, putative 0.0014 0.0451 0.5
Brugia malayi Protein kinase domain containing protein 0.0054 1 1
Echinococcus granulosus SH2 motif 0.0041 0.677 0.677
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis 0.0041 0.677 0.677
Plasmodium falciparum protein kinase, putative 0.0014 0.0451 0.5
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus granulosus tyrosine protein kinase 0.0014 0.0451 0.0451
Giardia lamblia Kinase, NEK 0.0014 0.0451 0.5
Schistosoma mansoni tyrosine kinase 0.0054 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0451 0.0451
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase pr2 0.0014 0.0451 0.0451
Loa Loa (eye worm) TK protein kinase 0.0054 1 1
Trypanosoma cruzi protein kinase, putative 0.0014 0.0451 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Plasmodium vivax protein kinase, putative 0.0014 0.0451 0.5
Schistosoma mansoni SH2A 0.0041 0.677 0.677
Echinococcus granulosus tensin 0.0041 0.677 0.677
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0014 0.0451 0.0451
Schistosoma mansoni vav2 0.0041 0.677 0.677
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0014 0.0451 0.0451
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0451 0.0451
Plasmodium falciparum tyrosine kinase-like protein 0.0014 0.0451 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.677 0.677
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0054 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0054 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0041 0.677 0.677
Schistosoma mansoni protein kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis activated cdc42 kinase 1 0.0014 0.0451 0.0451
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0451 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0014 0.0451 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0451 0.0451
Onchocerca volvulus 0.0054 1 1
Brugia malayi integrin-linked kinase 0.0014 0.0451 0.0451
Schistosoma mansoni serine/threonine RGC 0.0014 0.0451 0.0451
Schistosoma mansoni tyrosine protein kinase 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Loa Loa (eye worm) TK/ACK protein kinase 0.0014 0.0451 0.0451
Brugia malayi SH2 domain containing protein 0.0054 1 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0041 0.677 0.677
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0451 0.0451
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0014 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0014 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.677 0.677
Onchocerca volvulus 0.0054 1 1
Echinococcus granulosus SHC transforming protein 3 0.0041 0.677 0.677

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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