Detailed information for compound 1552540

Basic information

Technical information
  • TDR Targets ID: 1552540
  • Name: 1-(4-methylphenyl)sulfonyl-1,4-diazepan-5-one
  • MW: 268.332 | Formula: C12H16N2O3S
  • H donors: 1 H acceptors: 3 LogP: 0.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCCN(CC1)S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C12H16N2O3S/c1-10-2-4-11(5-3-10)18(16,17)14-8-6-12(15)13-7-9-14/h2-5H,6-9H2,1H3,(H,13,15)
  • InChiKey: BUBDJPVDFJRANO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • Oprea1_072120
  • ZINC01458116
  • MLS001033738
  • SMR000385675

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Echinococcus multilocularis tensin 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 1 1
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.1599 0.1599
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.2365 0.2365
Entamoeba histolytica SH2 domain containing protein 0.0092 0.7436 0.6949
Brugia malayi bone morphogenetic protein type 1 receptor 0.0028 0.1599 0.1599
Brugia malayi Variant SH3 domain containing protein 0.0092 0.7436 0.7436
Echinococcus multilocularis activin receptor type 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Srms 0.012 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine kinase 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0092 0.7436 0.7436
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0092 0.7436 0.7436
Brugia malayi hypothetical protein 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Onchocerca volvulus 0.012 1 1
Onchocerca volvulus 0.012 1 1
Schistosoma mansoni GTPase activating protein 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Onchocerca volvulus 0.0092 0.7436 0.6949
Echinococcus granulosus suppressor of cytokine signaling 7 0.0092 0.7436 0.7436
Toxoplasma gondii protein kinase 0.0028 0.1599 0.5
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.012 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase HCK 0.0028 0.1599 0.1599
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.2365 0.2365
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/DDR protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/EPH protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Fyn 0.012 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0028 0.1599 0.5
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni hypothetical protein 0.0092 0.7436 0.7436
Echinococcus granulosus ephrin type A receptor 4 A 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Echinococcus granulosus hypothetical protein 0.0092 0.7436 0.7436
Schistosoma mansoni tensin 0.0092 0.7436 0.7436
Schistosoma mansoni hypothetical protein 0.0092 0.7436 0.7436
Plasmodium falciparum tyrosine kinase-like protein 0.0028 0.1599 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.012 1 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0028 0.1599 0.1599
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.012 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis transfer RNA-Thr 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Trypanosoma cruzi protein kinase, putative 0.0028 0.1599 0.5
Schistosoma mansoni shc transforming protein 0.0092 0.7436 0.7436
Schistosoma mansoni tyrosine kinase 0.012 1 1
Brugia malayi protein-tyrosine kinase 0.012 1 1
Brugia malayi Tyrosine-protein kinase PR2 0.0028 0.1599 0.1599
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.2365 0.2365
Loa Loa (eye worm) TK/CSK protein kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.012 1 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Leishmania major protein kinase, putative 0.0028 0.1599 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Brugia malayi Tyrosine-protein kinase abl-1 0.012 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.1599 0.5
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0028 0.1599 0.1599
Echinococcus granulosus activated cdc42 kinase 1 0.0028 0.1599 0.1599
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0092 0.7436 0.7436
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0028 0.1599 0.1599
Brugia malayi SH2 domain containing protein 0.012 1 1
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus granulosus SH2 domain containing protein 7 0.0092 0.7436 0.7436
Brugia malayi hypothetical protein 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase HCK 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.012 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Leishmania major hypothetical protein, conserved 0.0028 0.1599 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.1925 0.1925
Echinococcus multilocularis NCK adaptor protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0028 0.1599 0.1599
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0028 0.1599 0.1599
Onchocerca volvulus 0.0092 0.7436 0.6949
Echinococcus granulosus tyrosine protein kinase csk 0.0028 0.1599 0.1599
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase shark 0.012 1 1
Echinococcus granulosus tensin 0.0092 0.7436 0.7436
Echinococcus granulosus activin receptor type 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Giardia lamblia Kinase, NEK 0.0028 0.1599 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0028 0.1599 0.1599
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.2146 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0028 0.1599 0.1599
Entamoeba histolytica SH2-protein kinase domain containing protein 0.012 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0028 0.1599 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Schistosoma mansoni tensin-related 0.0092 0.7436 0.7436
Loa Loa (eye worm) SRC-1 0.012 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0028 0.1599 0.1599
Echinococcus multilocularis insulin receptor 0.0028 0.1599 0.1599
Echinococcus multilocularis protein KINase family member (kin 25) 0.0028 0.1599 0.1599
Schistosoma mansoni ephrin receptor 0.0028 0.1599 0.1599
Schistosoma mansoni vav2 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.012 1 1
Echinococcus multilocularis protein tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0092 0.7436 0.7436
Loa Loa (eye worm) protein kinase domain-containing protein 0.0028 0.1599 0.1599
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0028 0.1599 0.1599
Echinococcus granulosus SH2 motif 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.012 1 1
Schistosoma mansoni ephrin receptor 0.0028 0.1599 0.1599
Onchocerca volvulus 0.012 1 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Fyn 0.012 1 1
Schistosoma mansoni protein tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) SH2 domain-containing protein 0.0092 0.7436 0.7436
Echinococcus multilocularis N chimaerin 0.0092 0.7436 0.7436
Giardia lamblia Kinase 0.0028 0.1599 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Schistosoma mansoni tyrosine kinase 0.012 1 1
Echinococcus granulosus expressed conserved protein 0.0092 0.7436 0.7436
Echinococcus multilocularis SH2 domain containing protein 7 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis activated cdc42 kinase 1 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Entamoeba histolytica protein kinase, putative 0.0092 0.7436 0.6949
Plasmodium vivax tyrosine kinase-like protein, putative 0.0028 0.1599 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.012 1 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0028 0.1599 0.1599
Brugia malayi Variant SH3 domain containing protein 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine kinase 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus granulosus fibroblast growth factor receptor 4 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0092 0.7436 0.7436
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.012 1 1
Brugia malayi C-terminal src kinase protein 1 0.0028 0.1599 0.1599
Onchocerca volvulus 0.0092 0.7436 0.6949
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0092 0.7436 0.6949
Echinococcus multilocularis tyrosine protein kinase csk 0.0028 0.1599 0.1599
Trypanosoma brucei Pseudokinase, putative 0.0028 0.1599 0.5
Brugia malayi hypothetical protein 0.012 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0092 0.7436 0.7436
Leishmania major protein kinase, putative 0.0028 0.1599 0.5
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.012 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Btk29A 0.012 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0092 0.7436 0.7436
Onchocerca volvulus 0.0092 0.7436 0.6949
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.012 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0092 0.7436 0.7436
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Onchocerca volvulus 0.0092 0.7436 0.6949
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis FL cytokine receptor 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus granulosus epidermal growth factor receptor 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Schistosoma mansoni tensin 0.0092 0.7436 0.7436
Echinococcus granulosus signal transduction protein lnk realted 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase shark 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus multilocularis growth factor receptor bound protein 2 0.0092 0.7436 0.7436
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus NCK adaptor protein 0.0092 0.7436 0.7436
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.012 1 1
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Brugia malayi ephrin receptor 1 precursor 0.0028 0.1599 0.1599
Onchocerca volvulus 0.012 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0092 0.7436 0.7436
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0028 0.1599 0.1599
Giardia lamblia Kinase, NEK 0.0028 0.1599 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.012 1 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0028 0.1599 0.1599
Trypanosoma brucei Flagellum attachment zone protein 20 0.0028 0.1599 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase csk 0.0028 0.1599 0.1599
Schistosoma mansoni nck2/grb4 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Onchocerca volvulus 0.012 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0028 0.1599 0.5
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus multilocularis natriuretic peptide receptor 1 0.0028 0.1599 0.1599
Loa Loa (eye worm) SH2 domain-containing protein 0.0092 0.7436 0.7436
Echinococcus multilocularis heat shock protein 70 0.0028 0.1599 0.1599
Echinococcus multilocularis SH2 motif 0.0092 0.7436 0.7436
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.1599 0.5
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis raf serine:threonine protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus activated cdc42 kinase 1 0.0028 0.1599 0.1599
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Schistosoma mansoni tyrosine kinase 0.012 1 1
Echinococcus multilocularis 0.0092 0.7436 0.7436
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0028 0.1599 0.1599
Echinococcus granulosus suppressor of cytokine signaling 6 0.0092 0.7436 0.7436
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus insulin receptor 0.0028 0.1599 0.1599
Brugia malayi Tensin 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/ACK protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/ROR protein kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Fyn 0.012 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.2146 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0092 0.7436 0.7436
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus granulosus SH2 motif 0.0092 0.7436 0.7436
Onchocerca volvulus 0.012 1 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine kinase 0.012 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0028 0.1599 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase Srms 0.012 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni voltage-gated potassium channel 0.004 0.2671 0.2671
Loa Loa (eye worm) TK protein kinase 0.012 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 1 1
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Lyn 0.012 1 1
Loa Loa (eye worm) STAT protein 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase Src42A 0.0092 0.7436 0.7436
Schistosoma mansoni growth factor receptor-bound protein 0.0092 0.7436 0.7436
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0092 0.7436 0.7436
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.1599 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni voltage-gated potassium channel 0.004 0.2671 0.2671
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Schistosoma mansoni SH2A 0.0092 0.7436 0.7436
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Brugia malayi integrin-linked kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis integrin linked protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0028 0.1599 0.1599
Schistosoma mansoni suppressor of cytokine signaling 0.0092 0.7436 0.7436
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.012 1 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0028 0.1599 0.1599
Brugia malayi Variant SH3 domain containing protein 0.0092 0.7436 0.7436
Echinococcus granulosus SHC transforming protein 3 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase Fgr 0.012 1 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0092 0.7436 0.6949
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase Blk 0.012 1 1
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase csk 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Echinococcus multilocularis SHC transforming protein 3 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 1 1
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0028 0.1599 0.1599
Echinococcus granulosus growth factor receptor bound protein 2 0.0092 0.7436 0.7436
Echinococcus granulosus tyrosine protein kinase Src42A 0.012 1 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0092 0.7436 0.7436
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Schistosoma mansoni hypothetical protein 0.0028 0.1599 0.1599
Plasmodium falciparum protein kinase, putative 0.0028 0.1599 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.012 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0092 0.7436 0.7436
Plasmodium falciparum protein kinase, putative 0.0028 0.1599 0.5
Giardia lamblia Protein 21.1 0.0028 0.1599 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0028 0.1599 0.1599
Brugia malayi Guanylyl cyclase protein 23 0.0028 0.1599 0.1599
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.2365 0.2365
Schistosoma mansoni tensin-related 0.0092 0.7436 0.7436
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Echinococcus multilocularis tensin 0.0092 0.7436 0.7436
Brugia malayi hypothetical protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/ALK protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0028 0.1599 0.1599
Schistosoma mansoni tensin 0.0092 0.7436 0.7436
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0028 0.1599 0.5
Onchocerca volvulus 0.0092 0.7436 0.6949
Echinococcus granulosus SH2 domain containing adapter protein F 0.0092 0.7436 0.7436
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.1599 0.1599
Plasmodium falciparum tyrosine kinase-like protein 0.0028 0.1599 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis kinase suppressor of Ras 1 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase ABL1 0.012 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0092 0.7436 0.7436
Brugia malayi SH2 domain containing protein 0.012 1 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus c src tyrosine kinase 0.012 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0092 0.7436 0.7436
Toxoplasma gondii protein kinase domain-containing protein 0.0028 0.1599 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0092 0.7436 0.7436
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase csk 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0092 0.7436 0.7436
Echinococcus multilocularis SH2 motif 0.0092 0.7436 0.7436
Echinococcus multilocularis epidermal growth factor receptor 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase ABL1 0.012 1 1
Brugia malayi Raf kinase 0.0028 0.1599 0.1599
Echinococcus granulosus protein tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Schistosoma mansoni adapter molecule crk 0.0092 0.7436 0.7436
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/ABL protein kinase 0.012 1 1
Echinococcus multilocularis c src tyrosine kinase 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.012 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0028 0.1599 0.1599
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0028 0.1599 0.1599
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.1599 0.1599
Schistosoma mansoni serine/threonine RGC 0.0028 0.1599 0.1599
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0092 0.7436 0.7436
Plasmodium falciparum protein kinase, putative 0.0028 0.1599 0.5
Echinococcus multilocularis protein kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.012 1 1
Brugia malayi SRC-1 0.012 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0028 0.1599 0.1599
Echinococcus granulosus kinase suppressor of Ras 1 0.0028 0.1599 0.1599
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0028 0.1599 0.1599
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0092 0.7436 0.6949
Echinococcus granulosus integrin linked protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein kinase pr2 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Trypanosoma brucei protein kinase, putative 0.0028 0.1599 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Echinococcus granulosus receptor type guanylyl cyclase 0.0028 0.1599 0.1599
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0092 0.7436 0.7436
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0028 0.1599 0.1599
Brugia malayi Protein kinase domain containing protein 0.0028 0.1599 0.1599
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Echinococcus multilocularis SH2 motif 0.0092 0.7436 0.7436
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase Src64B 0.012 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 1 1
Schistosoma mansoni protein kinase 0.0028 0.1599 0.1599
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0092 0.7436 0.7436
Brugia malayi Protein kinase domain containing protein 0.012 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.012 1 1
Brugia malayi Sex muscle abnormal protein 5 0.0092 0.7436 0.7436
Echinococcus granulosus N chimaerin 0.0092 0.7436 0.7436
Brugia malayi Variant SH3 domain containing protein 0.0092 0.7436 0.7436
Echinococcus granulosus natriuretic peptide receptor 1 0.0028 0.1599 0.1599
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599
Brugia malayi RhoGAP domain containing protein 0.0092 0.7436 0.7436
Echinococcus multilocularis receptor type guanylyl cyclase 0.0028 0.1599 0.1599
Echinococcus granulosus tyrosine protein kinase csk 0.0028 0.1599 0.1599
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase csk 0.0028 0.1599 0.1599
Plasmodium vivax protein kinase, putative 0.0028 0.1599 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.012 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.7436 0.7436
Echinococcus multilocularis tyrosine protein kinase Abl 0.012 1 1
Echinococcus granulosus tyrosine kinase 0.0028 0.1599 0.1599
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0028 0.1599 0.1599
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0028 0.1599 0.1599
Brugia malayi SH2 domain containing protein 0.0092 0.7436 0.7436
Schistosoma mansoni suppressor of cytokine signaling 0.0092 0.7436 0.7436
Brugia malayi STAT protein, DNA binding domain containing protein 0.0092 0.7436 0.7436
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.1599 0.1599
Toxoplasma gondii STE kinase 0.0028 0.1599 0.5
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0028 0.1599 0.1599
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0092 0.7436 0.7436
Trypanosoma cruzi protein kinase, putative 0.0028 0.1599 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.012 1 1
Schistosoma mansoni tyrosine kinase 0.0028 0.1599 0.1599

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.