TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 507.605 | Formula: C26H29N5O4S
H donors: 2 H acceptors: 4 LogP: 2.39 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CN(C(=O)c1ccc(cc1)NC(=O)CC1SC(=NC1=O)N1CCCC1)CC(=O)Nc1ccc(cc1)C
InChi: 1S/C26H29N5O4S/c1-17-5-9-19(10-6-17)28-23(33)16-30(2)25(35)18-7-11-20(12-8-18)27-22(32)15-21-24(34)29-26(36-21)31-13-3-4-14-31/h5-12,21H,3-4,13-16H2,1-2H3,(H,27,32)(H,28,33)
InChiKey: FFHNSVBMDCTNMS-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SH2 domain containing protein	0.0131	0.5982	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0032	0.0611	0.1022
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0099	0.4231	0.7072
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/ACK protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0032	0.0611	0.0611
Leishmania major	hypothetical protein, conserved	0.0032	0.0611	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0131	0.5982	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0131	0.5982	0.5982
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	tensin-related	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0099	0.4231	0.4231
Schistosoma mansoni	GTPase activating protein	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine kinase	0.0131	0.5982	0.5982
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0032	0.0611	0.1022
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0099	0.4231	0.6739
Echinococcus granulosus	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Schistosoma mansoni	voltage-gated potassium channel	0.0079	0.3157	0.3157
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0131	0.5982	0.5982
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Echinococcus multilocularis	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Brugia malayi	ephrin receptor 1 precursor	0.0032	0.0611	0.1022
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0032	0.0611	0.0611
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0131	0.5982	0.5982
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Entamoeba histolytica	protein kinase, putative	0.0099	0.4231	0.6739
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Onchocerca volvulus		0.0131	0.5982	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0099	0.4231	0.7072
Echinococcus granulosus	tyrosine kinase	0.0131	0.5982	0.5982
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0099	0.4231	0.4231
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0099	0.4231	0.4231
Loa Loa (eye worm)	TK/ALK protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	hypothetical protein	0.0099	0.4231	0.4231
Echinococcus granulosus	tyrosine kinase	0.0131	0.5982	0.5982
Echinococcus granulosus	SH2 domain containing protein 7	0.0099	0.4231	0.4231
Echinococcus multilocularis	integrin linked protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0032	0.0611	0.0611
Echinococcus granulosus	SH2 motif	0.0099	0.4231	0.4231
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0032	0.0611	0.0611
Schistosoma mansoni	suppressor of cytokine signaling	0.0099	0.4231	0.4231
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0099	0.4231	0.7072
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0032	0.0611	0.0611
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0131	0.5982	0.5982
Onchocerca volvulus		0.0131	0.5982	1
Echinococcus multilocularis	SH2 motif	0.0099	0.4231	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2276	0.3804
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0099	0.4231	0.4231
Echinococcus multilocularis	activin receptor type	0.0032	0.0611	0.0611
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0131	0.5982	0.5982
Echinococcus multilocularis	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Echinococcus multilocularis	protein kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0099	0.4231	0.4231
Echinococcus granulosus	ephrin type A receptor 4 A	0.0032	0.0611	0.0611
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0041	0.11	0.1839
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0072	0.2795	0.2795
Echinococcus multilocularis	epidermal growth factor receptor	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	NCK adaptor protein	0.0099	0.4231	0.4231
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	protein tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	SH2A	0.0099	0.4231	0.4231
Trypanosoma brucei	protein kinase, putative	0.0032	0.0611	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Echinococcus granulosus	c src tyrosine kinase	0.0131	0.5982	0.5982
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0032	0.0611	0.0611
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0072	0.2795	0.4673
Onchocerca volvulus		0.0099	0.4231	0.6739
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Brugia malayi	protein-tyrosine kinase	0.0131	0.5982	1
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Onchocerca volvulus		0.0099	0.4231	0.6739
Echinococcus granulosus	activated cdc42 kinase 1	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	c src tyrosine kinase	0.0131	0.5982	0.5982
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.2137	0.3573
Brugia malayi	Tyrosine-protein kinase PR2	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0099	0.4231	0.4231
Onchocerca volvulus		0.0099	0.4231	0.6739
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/FAK protein kinase	0.0032	0.0611	0.1022
Brugia malayi	SH2 domain containing protein	0.0131	0.5982	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0032	0.0611	0.0611
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Brugia malayi	Guanylyl cyclase protein 23	0.0032	0.0611	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	tensin	0.0099	0.4231	0.4231
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0131	0.5982	0.5982
Schistosoma mansoni	serine/threonine RGC	0.0032	0.0611	0.0611
Trypanosoma cruzi	protein kinase, putative	0.0032	0.0611	0.5
Schistosoma mansoni	tyrosine kinase	0.0131	0.5982	0.5982
Echinococcus granulosus	natriuretic peptide receptor 1	0.0032	0.0611	0.0611
Brugia malayi	Variant SH3 domain containing protein	0.0099	0.4231	0.7072
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	tensin	0.0099	0.4231	0.4231
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Toxoplasma gondii	protein kinase domain-containing protein	0.0032	0.0611	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0032	0.0611	0.0611
Schistosoma mansoni	ephrin receptor	0.0032	0.0611	0.0611
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	SH2 domain containing protein 7	0.0099	0.4231	0.4231
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0611	0.0611
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0099	0.4231	0.7072
Brugia malayi	Receptor family ligand binding region containing protein	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0099	0.4231	0.4231
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0032	0.0611	0.0611
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	SRC-1	0.0131	0.5982	1
Brugia malayi	Tensin	0.0099	0.4231	0.7072
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	FL cytokine receptor	0.0032	0.0611	0.0611
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	SH2 domain-containing protein	0.0099	0.4231	0.7072
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0099	0.4231	0.4231
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0131	0.5982	0.5982
Echinococcus granulosus	SH2 motif	0.0099	0.4231	0.4231
Schistosoma mansoni	suppressor of cytokine signaling	0.0099	0.4231	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	tyrosine protein kinase shark	0.0131	0.5982	0.5982
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	protein kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0099	0.4231	0.4231
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0131	0.5982	0.5982
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0131	0.5982	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0099	0.4231	0.7072
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0099	0.4231	0.4231
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0032	0.0611	0.0611
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Trypanosoma brucei	Pseudokinase, putative	0.0032	0.0611	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0099	0.4231	0.4231
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0131	0.5982	0.5982
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0032	0.0611	0.0611
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0032	0.0611	0.0611
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	protein tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	insulin receptor	0.0032	0.0611	0.0611
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0611	0.0611
Onchocerca volvulus		0.0099	0.4231	0.6739
Loa Loa (eye worm)	SH2 domain-containing protein	0.0099	0.4231	0.7072
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Brugia malayi	Furin-like cysteine rich region family protein	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0131	0.5982	0.5982
Echinococcus multilocularis	tyrosine protein kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	expressed conserved protein	0.0099	0.4231	0.4231
Loa Loa (eye worm)	serine/threonine protein kinase	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase pr2	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK/ABL protein kinase	0.0131	0.5982	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0099	0.4231	0.4231
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0099	0.4231	0.7072
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0032	0.0611	0.5
Onchocerca volvulus		0.0131	0.5982	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0032	0.0611	0.1022
Trypanosoma cruzi	protein kinase, putative	0.0032	0.0611	0.5
Giardia lamblia	Kinase, NEK	0.0032	0.0611	0.5
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0032	0.0611	0.0611
Echinococcus granulosus	tyrosine protein kinase Blk	0.0131	0.5982	0.5982
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0099	0.4231	0.4231
Onchocerca volvulus		0.0131	0.5982	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0099	0.4231	0.4231
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0099	0.4231	0.7072
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0032	0.0611	0.5
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	signal transduction protein lnk realted	0.0099	0.4231	0.4231
Echinococcus multilocularis		0.0099	0.4231	0.4231
Plasmodium vivax	protein kinase, putative	0.0032	0.0611	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0032	0.0611	0.0611
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Echinococcus multilocularis	SH2 motif	0.0099	0.4231	0.4231
Brugia malayi	Tyrosine-protein kinase abl-1	0.0131	0.5982	1
Echinococcus granulosus	tyrosine protein kinase	0.0032	0.0611	0.0611
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0131	0.5982	1
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0032	0.0611	0.0611
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0099	0.4231	0.7072
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Echinococcus granulosus	NCK adaptor protein	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Giardia lamblia	Protein 21.1	0.0032	0.0611	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.2536	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.2536	1
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	protein tyrosine kinase	0.0032	0.0611	0.0611
Onchocerca volvulus		0.0131	0.5982	1
Schistosoma mansoni	tensin-related	0.0099	0.4231	0.4231
Echinococcus granulosus	integrin linked protein kinase	0.0032	0.0611	0.0611
Brugia malayi	C-terminal src kinase protein 1	0.0032	0.0611	0.1022
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.11	0.1839
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Schistosoma mansoni	tyrosine kinase	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Schistosoma mansoni	vav2	0.0099	0.4231	0.4231
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Echinococcus granulosus	activin receptor type	0.0032	0.0611	0.0611
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0032	0.0611	0.5
Brugia malayi	hypothetical protein	0.0131	0.5982	1
Echinococcus granulosus	tensin	0.0099	0.4231	0.4231
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0072	0.2795	0.4673
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0032	0.0611	0.0611
Brugia malayi	RhoGAP domain containing protein	0.0099	0.4231	0.7072
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0131	0.5982	0.5982
Brugia malayi	hypothetical protein	0.0032	0.0611	0.1022
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0032	0.0611	0.5
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Schistosoma mansoni	ephrin receptor	0.0032	0.0611	0.0611
Schistosoma mansoni	signal transduction protein lnk-related	0.0099	0.4231	0.4231
Entamoeba histolytica	SH2 domain containing protein	0.0099	0.4231	0.6739
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	geminin	0.0205	1	1
Echinococcus multilocularis	N chimaerin	0.0099	0.4231	0.4231
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Toxoplasma gondii	STE kinase	0.0032	0.0611	0.5
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Loa Loa (eye worm)	TK/Met protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	nck2/grb4	0.0099	0.4231	0.4231
Loa Loa (eye worm)	TK/RYK protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Giardia lamblia	Kinase	0.0032	0.0611	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK/ROR protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0131	0.5982	0.5982
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0131	0.5982	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0131	0.5982	0.5982
Echinococcus granulosus	activated cdc42 kinase 1	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	kinase suppressor of Ras 1	0.0032	0.0611	0.0611
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Brugia malayi	Variant SH3 domain containing protein	0.0099	0.4231	0.7072
Toxoplasma gondii	protein kinase	0.0032	0.0611	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0032	0.0611	0.5
Brugia malayi	SH2 domain containing protein	0.0099	0.4231	0.7072
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK/CSK protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	growth factor receptor-bound protein	0.0099	0.4231	0.4231
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0131	0.5982	0.5982
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0099	0.4231	0.4231
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0099	0.4231	0.4231
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0032	0.0611	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0131	0.5982	0.5982
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Schistosoma mansoni	tensin	0.0099	0.4231	0.4231
Echinococcus multilocularis	transfer RNA-Thr	0.0032	0.0611	0.0611
Echinococcus multilocularis	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Schistosoma mansoni	shc transforming protein	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Plasmodium falciparum	protein kinase, putative	0.0032	0.0611	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0099	0.4231	0.4231
Brugia malayi	hypothetical protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	SHC transforming protein 3	0.0099	0.4231	0.4231
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Brugia malayi	integrin-linked kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0099	0.4231	0.4231
Echinococcus granulosus	SHC transforming protein 3	0.0099	0.4231	0.4231
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0099	0.4231	0.4231
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0099	0.4231	0.4231
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus granulosus	N chimaerin	0.0099	0.4231	0.4231
Schistosoma mansoni	hypothetical protein	0.0032	0.0611	0.0611
Plasmodium falciparum	tyrosine kinase-like protein	0.0032	0.0611	0.5
Schistosoma mansoni	hypothetical protein	0.0041	0.11	0.11
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0032	0.0611	0.1022
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0032	0.0611	0.5
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0131	0.5982	0.5982
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Brugia malayi	Protein kinase domain containing protein	0.0131	0.5982	1
Plasmodium falciparum	protein kinase, putative	0.0032	0.0611	0.5
Onchocerca volvulus		0.0099	0.4231	0.6739
Echinococcus granulosus	tyrosine protein kinase shark	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK protein kinase	0.0032	0.0611	0.1022
Schistosoma mansoni	growth factor receptor-bound protein	0.0099	0.4231	0.4231
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.2137	0.3573
Brugia malayi	hypothetical protein	0.0099	0.4231	0.7072
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus granulosus	growth factor receptor bound protein 2	0.0099	0.4231	0.4231
Plasmodium falciparum	tyrosine kinase-like protein	0.0032	0.0611	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK protein kinase	0.0131	0.5982	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0032	0.0611	0.0611
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0099	0.4231	0.4231
Onchocerca volvulus		0.0099	0.4231	0.6739
Brugia malayi	Raf kinase	0.0032	0.0611	0.1022
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0131	0.5982	0.5982
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.2137	0.3573
Echinococcus granulosus	epidermal growth factor receptor	0.0032	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0032	0.0611	0.0611
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	STAT protein	0.0099	0.4231	0.7072
Schistosoma mansoni	hypothetical protein	0.0099	0.4231	0.4231
Echinococcus granulosus	receptor type guanylyl cyclase	0.0032	0.0611	0.0611
Giardia lamblia	Kinase, NEK	0.0032	0.0611	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0099	0.4231	0.6739
Leishmania major	protein kinase, putative	0.0032	0.0611	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0611	0.1022
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0072	0.2795	0.2795
Echinococcus granulosus	epidermal growth factor receptor	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0032	0.0611	0.1022
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0099	0.4231	0.7072
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0032	0.0611	0.5
Schistosoma mansoni	tensin	0.0099	0.4231	0.4231
Schistosoma mansoni	voltage-gated potassium channel	0.0079	0.3157	0.3157
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0099	0.4231	0.4231
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0131	0.5982	0.5982
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0032	0.0611	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Brugia malayi	Variant SH3 domain containing protein	0.0099	0.4231	0.7072
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0032	0.0611	0.1022
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0032	0.0611	0.0611
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0032	0.0611	0.0611
Brugia malayi	Variant SH3 domain containing protein	0.0099	0.4231	0.7072
Onchocerca volvulus		0.0131	0.5982	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1022
Leishmania major	protein kinase, putative	0.0032	0.0611	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0099	0.4231	0.7072
Plasmodium falciparum	protein kinase, putative	0.0032	0.0611	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0131	0.5982	0.5982
Echinococcus multilocularis	epidermal growth factor receptor	0.0032	0.0611	0.0611
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0099	0.4231	0.4231
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0032	0.0611	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus granulosus	hypothetical protein	0.0099	0.4231	0.4231
Echinococcus multilocularis	insulin receptor	0.0032	0.0611	0.0611
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0032	0.0611	0.0611
Schistosoma mansoni	adapter molecule crk	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine protein kinase	0.0032	0.0611	0.0611
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0099	0.4231	0.6739
Brugia malayi	Protein kinase domain containing protein	0.0131	0.5982	1
Echinococcus multilocularis	SH2 motif	0.0099	0.4231	0.4231
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Schistosoma mansoni	tensin	0.0099	0.4231	0.4231
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0032	0.0611	0.1022
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0131	0.5982	0.5982
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.5982	1
Echinococcus multilocularis	tyrosine kinase	0.0131	0.5982	0.5982
Loa Loa (eye worm)	hypothetical protein	0.0099	0.4231	0.7072
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0032	0.0611	0.0611
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0032	0.0611	0.0611
Echinococcus granulosus	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0131	0.5982	0.5982
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0099	0.4231	0.7072
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Echinococcus granulosus	protein kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0099	0.4231	0.4231
Schistosoma mansoni	tyrosine kinase	0.0032	0.0611	0.0611
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0032	0.0611	0.0611
Echinococcus multilocularis	heat shock protein 70	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.006	0.2137	0.3573
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0032	0.0611	0.0611
Brugia malayi	SRC-1	0.0131	0.5982	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0032	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0131	0.5982	1
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0611	0.1022
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0611	0.1022
Echinococcus granulosus	tyrosine protein kinase csk	0.0032	0.0611	0.0611
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0032	0.0611	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.1582 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	84.9214 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1881042

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1552548