Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0043 | 0.028 | 0.0936 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0043 | 0.028 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.028 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0181 | 0.2993 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0043 | 0.028 | 0.028 |
Toxoplasma gondii | prolyl endopeptidase | 0.0043 | 0.028 | 0.0936 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0181 | 0.2993 | 0.2993 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.5384 | 0.5384 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0181 | 0.2993 | 0.2993 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0538 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0043 | 0.028 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0302 | 0.5384 | 0.5384 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0043 | 0.028 | 0.028 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0302 | 0.5384 | 0.5384 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0538 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.1026 | 0.1026 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0043 | 0.028 | 0.028 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0043 | 0.028 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0043 | 0.028 | 0.028 |
Brugia malayi | hypothetical protein | 0.0138 | 0.2156 | 0.2156 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0538 | 1 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0043 | 0.028 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0043 | 0.028 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0043 | 0.028 | 0.028 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0043 | 0.028 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0043 | 0.028 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0538 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0043 | 0.028 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0043 | 0.028 | 0.028 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0043 | 0.028 | 0.028 |
Trypanosoma brucei | oligopeptidase b | 0.0043 | 0.028 | 0.0936 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0181 | 0.2993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.028 | 0.028 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0181 | 0.2993 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0043 | 0.028 | 0.0936 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0043 | 0.028 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0043 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.028 | 0.028 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0538 | 1 | 1 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0043 | 0.028 | 0.0936 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0181 | 0.2993 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0181 | 0.2993 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0043 | 0.028 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0043 | 0.028 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0043 | 0.028 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.028 | 0.028 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0043 | 0.028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2156 | 0.2156 |
Echinococcus granulosus | prolyl endopeptidase | 0.0043 | 0.028 | 0.028 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0043 | 0.028 | 0.0936 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0043 | 0.028 | 0.028 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0043 | 0.028 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0181 | 0.2993 | 1 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0043 | 0.028 | 0.028 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.028 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0181 | 0.2993 | 0.2993 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0043 | 0.028 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0043 | 0.028 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0302 | 0.5384 | 0.5384 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0043 | 0.028 | 0.028 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0181 | 0.2993 | 0.2993 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0043 | 0.028 | 0.0936 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.