Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.376 | 0.511 |
Echinococcus granulosus | tar DNA binding protein | 0.0204 | 0.7358 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0204 | 0.7358 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0204 | 0.7358 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.376 | 0.511 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0204 | 0.7358 | 1 |
Brugia malayi | TAR-binding protein | 0.0204 | 0.7358 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0204 | 0.7358 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0204 | 0.7358 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0204 | 0.7358 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0204 | 0.7358 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0204 | 0.7358 | 1 |
Brugia malayi | RNA binding protein | 0.0204 | 0.7358 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.376 | 0.511 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0204 | 0.7358 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0204 | 0.7358 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.