Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | No references |
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 633 aa | 616 aa | 38.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0101 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0101 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Brugia malayi | hypothetical protein | 0.008 | 0.7371 | 0.7371 |
Plasmodium vivax | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.9288 | 0.961 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.9288 | 0.9288 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.9288 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.9664 | 1 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.7706 | 0.8297 |
Plasmodium vivax | amine transporter, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.7706 | 0.8297 |
Onchocerca volvulus | 0.008 | 0.7371 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9288 | 0.961 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9288 | 0.961 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Plasmodium falciparum | amino acid transporter, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.9288 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 80.1 nM | Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting | ChEMBL. | 21975065 |
IC50 (binding) | = 314 nM | Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting | ChEMBL. | 21975065 |
Potency (functional) | 2.1872 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.3553 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.4938 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 24.5412 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 43.6412 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.1306 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 77.6062 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.