Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | No references |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | Starlite/ChEMBL | References |
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 633 aa | 616 aa | 38.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9288 | 0.961 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.7706 | 0.8297 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.9288 | 0.9288 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.008 | 0.7371 | 1 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.9288 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.7371 | 0.7371 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Echinococcus granulosus | jun protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.7706 | 0.8297 |
Plasmodium vivax | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9288 | 0.961 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0019 | 0 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.9288 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.9288 | 0.961 |
Plasmodium falciparum | amino acid transporter, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.9664 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Echinococcus multilocularis | jun protein | 0.0101 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 80.1 nM | Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting | ChEMBL. | 21975065 |
IC50 (binding) | = 314 nM | Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting | ChEMBL. | 21975065 |
Potency (functional) | 2.1872 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.3553 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.4938 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 24.5412 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 43.6412 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.1306 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 77.6062 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.