Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1869 | 0.1869 |
Onchocerca volvulus | 0.0108 | 0.2138 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.0108 | 0.2138 | 0.2138 |
Brugia malayi | Dihydrofolate reductase | 0.0391 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0285 | 0.7048 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0391 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0285 | 0.7048 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0108 | 0.2138 | 0.2137 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1004 | 0.1004 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.2471 | 0.2471 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0391 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0563 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.2471 | 0.2471 |
Brugia malayi | thymidylate synthase | 0.0108 | 0.2138 | 0.2138 |
Echinococcus multilocularis | thymidylate synthase | 0.0108 | 0.2138 | 0.2138 |
Loa Loa (eye worm) | thymidylate synthase | 0.0108 | 0.2138 | 0.2138 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0051 | 0.0563 | 0.0797 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.1869 | 0.1869 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0391 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0391 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0285 | 0.7048 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0001 | 0.0001 |
Schistosoma mansoni | dihydrofolate reductase | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0391 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1004 | 0.1004 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0108 | 0.2138 | 0.2138 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0285 | 0.7048 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.2471 | 0.2471 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1004 | 0.1004 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0285 | 0.7048 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0285 | 0.7048 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.1869 | 0.1869 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0001 | 0.0001 |
Echinococcus granulosus | dihydrofolate reductase | 0.0391 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.1869 | 0.1869 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0051 | 0.0563 | 0.0562 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0563 | 0.0563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.