Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 8B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glyoxalase I | 0.0443 | 1 | 1 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0103 | 0 | 0.5 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.0443 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0282 | 0.0282 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0198 | 0.2792 | 0.4658 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0269 | 0.489 | 0.8943 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0548 | 0.0548 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0289 | 0.5468 | 0.5468 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0282 | 0.0282 |
Brugia malayi | C1-like domain containing protein | 0.0236 | 0.3913 | 0.3913 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0289 | 0.5468 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Onchocerca volvulus | 0.0162 | 0.1751 | 0.1751 | |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0121 | 0.0548 | 0.0548 |
Echinococcus multilocularis | protein kinase c iota type | 0.0227 | 0.3654 | 0.6379 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0211 | 0.3186 | 0.5445 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0269 | 0.489 | 0.8846 |
Toxoplasma gondii | glyoxalase I, putative | 0.0443 | 1 | 1 |
Onchocerca volvulus | 0.0239 | 0.401 | 0.401 | |
Onchocerca volvulus | 0.0276 | 0.5085 | 0.5085 | |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0289 | 0.5468 | 0.5468 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0127 | 0.0707 | 0.0707 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0146 | 0.1262 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5085 | 0.5085 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0121 | 0.0548 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7234 | 0.7234 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0164 | 0.1815 | 0.1815 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1751 | 0.1751 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0249 | 0.431 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0269 | 0.489 | 0.8846 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0269 | 0.489 | 0.8943 |
Schistosoma mansoni | atypical protein kinase C | 0.0233 | 0.3832 | 0.7007 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.0443 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.2557 | 0.2557 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0103 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0289 | 0.5468 | 1 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0103 | 0 | 0.5 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0236 | 0.3913 | 0.3913 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5085 | 0.5085 |
Onchocerca volvulus | 0.0234 | 0.3849 | 0.3849 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.7183 | 0.7183 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0162 | 0.1747 | 0.1747 |
Mycobacterium tuberculosis | Conserved protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0236 | 0.3913 | 0.3913 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | protein kinase C mu | 0.0236 | 0.3913 | 0.7156 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0289 | 0.5468 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.0443 | 1 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0443 | 1 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0198 | 0.2792 | 0.4658 |
Mycobacterium tuberculosis | Conserved protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3849 | 0.3849 |
Brugia malayi | protein kinase C3,putative | 0.0156 | 0.1569 | 0.1569 |
Echinococcus granulosus | protein kinase c iota type | 0.0227 | 0.3654 | 0.6379 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5085 | 0.5085 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1751 | 0.1751 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0121 | 0.0548 | 0.0548 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.014 | 0.1101 | 0.1282 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.401 | 0.401 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0443 | 1 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0198 | 0.2805 | 0.2805 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 65 nM | Inhibition of PDE8B | ChEMBL. | 21459572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.