Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0468 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0062 | 0.3325 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0038 | 0.1472 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0062 | 0.3325 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.0468 | 0.3182 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0038 | 0.1472 | 0.4426 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0706 | 0.0833 |
Loa Loa (eye worm) | fibroinase | 0.0038 | 0.1472 | 0.3513 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0062 | 0.3325 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.1055 | 0.2055 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1472 | 0.3513 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0115 | 0.7525 | 0.7525 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0038 | 0.1472 | 0.3513 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0038 | 0.1472 | 0.4426 |
Onchocerca volvulus | Cathepsin F homolog | 0.0038 | 0.1472 | 0.3513 |
Onchocerca volvulus | Cathepsin L homolog | 0.0038 | 0.1472 | 0.3513 |
Plasmodium vivax | vivapain-2 | 0.0038 | 0.1472 | 1 |
Echinococcus multilocularis | musashi | 0.0062 | 0.3325 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0468 | 0.1408 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Brugia malayi | intermediate filament protein | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus granulosus | lamin | 0.0062 | 0.3325 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0147 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0062 | 0.3325 | 1 |
Leishmania major | cathepsin L-like protease | 0.0147 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.0468 | 0.1408 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3235 | 0.9687 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0468 | 0.3182 |
Loa Loa (eye worm) | ctsf protein | 0.0038 | 0.1472 | 0.3513 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.0468 | 0.1408 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0468 | 0.1408 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0038 | 0.1472 | 0.4426 |
Loa Loa (eye worm) | intermediate filament protein | 0.0062 | 0.3325 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0038 | 0.1472 | 0.3513 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Echinococcus multilocularis | cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0026 | 0.0468 | 0.1408 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0038 | 0.1472 | 0.4426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.3325 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0134 | 0.8997 | 0.8997 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0796 | 0.1146 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Schistosoma mansoni | lamin | 0.0062 | 0.3325 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.003 | 0.0796 | 0.2393 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0026 | 0.0468 | 0.1408 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0062 | 0.3325 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Schistosoma mansoni | intermediate filament proteins | 0.0062 | 0.3325 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.003 | 0.0796 | 0.2393 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0038 | 0.1472 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3325 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0033 | 0.1055 | 0.3174 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0038 | 0.1472 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.1472 | 0.4426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0038 | 0.1472 | 0.4426 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0706 | 0.0833 |
Echinococcus multilocularis | lamin dm0 | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0038 | 0.1472 | 0.1472 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0038 | 0.1472 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0062 | 0.3325 | 1 |
Schistosoma mansoni | lamin | 0.0062 | 0.3325 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.1472 | 0.4426 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 45 % | Inhibition of human ICMT at 10 uM incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | ChEMBL. | 21334890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.