Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | _UBC13, UbcH-ben, UbcH13 | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2, putative | _UBC13, UbcH-ben, UbcH13 | 152 aa | 153 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0046 | 0.5267 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.5267 | 0.5 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0046 | 0.5267 | 0.5267 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0046 | 0.5267 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0046 | 0.5267 | 0.5267 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.5267 | 0.5 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.5267 | 0.5267 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0046 | 0.5267 | 0.5267 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0046 | 0.5267 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.5267 | 0.5 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.5267 | 0.5267 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.5267 | 0.5267 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0046 | 0.5267 | 0.5 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0046 | 0.5267 | 0.5 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0046 | 0.5267 | 0.5267 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0046 | 0.5267 | 0.5 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0046 | 0.5267 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.431 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493155] | ChEMBL. | No reference |
IC50 (functional) | = 6.504 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.