Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0008 | 0.0305 | 0.1459 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0034 | 0.2032 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1772 | 0.8468 |
Brugia malayi | Pleckstrin Homology Domain | 0.0005 | 0.0061 | 0.0299 |
Schistosoma mansoni | vav2 | 0.0005 | 0.0061 | 0.0299 |
Echinococcus granulosus | myotubularin protein 13 | 0.0005 | 0.0061 | 1 |
Onchocerca volvulus | 0.0034 | 0.2025 | 0.7864 | |
Brugia malayi | Cytochrome P450 family protein | 0.0008 | 0.0305 | 0.1503 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0143 | 0.0682 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0061 | 0.029 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0151 | 1 | 1 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0005 | 0.0061 | 1 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1772 | 0.8468 |
Onchocerca volvulus | 0.0035 | 0.2093 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2025 | 0.9673 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0034 | 0.2032 | 0.971 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0151 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0008 | 0.0305 | 0.1503 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0008 | 0.0305 | 0.1459 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0008 | 0.0305 | 0.1459 |
Brugia malayi | C1-like domain containing protein | 0.0034 | 0.2032 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.003 | 0.178 | 0.8504 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0008 | 0.0305 | 0.5 |
Schistosoma mansoni | protein kinase C mu | 0.0034 | 0.2032 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.