TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 433.546 | Formula: C25H31N5O2
H donors: 2 H acceptors: 3 LogP: 2.95 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@H]1CN(C[C@@H](C1)C(=O)NCc1cccc(n1)N)Cc1nc(oc1C)c1ccccc1
InChi: 1S/C25H31N5O2/c1-3-18-12-20(24(31)27-13-21-10-7-11-23(26)28-21)15-30(14-18)16-22-17(2)32-25(29-22)19-8-5-4-6-9-19/h4-11,18,20H,3,12-16H2,1-2H3,(H2,26,28)(H,27,31)/t18-,20-/m1/s1
InChiKey: UIMPAJVJPBIYQJ-UYAOXDASSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 8B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130653	All targets in OG5_130653
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	Get druggable targets OG5_130653	All targets in OG5_130653
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_130653	All targets in OG5_130653
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_130653	All targets in OG5_130653
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_130653	All targets in OG5_130653
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130653	All targets in OG5_130653
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130653	All targets in OG5_130653
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_130653	All targets in OG5_130653
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130653	All targets in OG5_130653
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	Get druggable targets OG5_130653	All targets in OG5_130653

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0211	0.0237
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0211	0.0237
Echinococcus multilocularis	serotonin receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0211	0.0237
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	lamin	0.0028	0.0718	0.2659
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0185	0.0185
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0211	0.0211
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0011	0.0017	0.0017
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0016	0.0211	0.0736
Schistosoma mansoni	amine GPCR	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0112	0.4156	0.4156
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0064	0.2205	0.2205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0718	0.0804
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0124	0.0406
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0414	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0016	0.0211	0.0736
Schistosoma mansoni	amine GPCR	0.0016	0.0211	0.0237
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0011	0.00000000034777	0.00000000034777
Brugia malayi	GnHR receptor homolog	0.0016	0.0211	0.0194
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.037	0.1341
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0211	0.0211
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0211	0.0237
Echinococcus granulosus	7tm_1 domain containing protein	0.0016	0.0211	0.0736
Loa Loa (eye worm)	ets-domain-containing protein	0.0011	0.0017	0.0017
Echinococcus granulosus	neuropeptide FF receptor 2	0.0016	0.0211	0.0736
Echinococcus granulosus	serotonin receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0211	0.0736
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	g-protein coupled receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.037	0.7482
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.037	1
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0211	0.0211
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.0211	0.0194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Echinococcus multilocularis	neuropeptide s receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	fmrfamide receptor	0.0016	0.0211	0.0736
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0414	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.037	1
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	Dopamine receptor	0.0016	0.0211	0.0194
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0255	1	1
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0211	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Brugia malayi	intermediate filament protein	0.0028	0.0718	0.0702
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0016	0.0211	0.0736
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.0211	0.0194
Echinococcus granulosus	g-protein coupled receptor	0.0016	0.0211	0.0736
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.037	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0718	0.0702
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0414	0.1505
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.037	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0211	0.0237
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0211	0.0736
Echinococcus granulosus	orexin receptor type 2	0.0016	0.0211	0.0736
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0016	0.0211	0.0237
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Schistosoma mansoni	growth hormone secretagogue receptor	0.0016	0.0211	0.0237
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0414	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0242	0.5863
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0011	0.0017	0.0019
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0124	0.0124
Echinococcus multilocularis	orexin receptor type 2	0.0016	0.0211	0.0736
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0211	0.0211
Schistosoma mansoni	hypothetical protein	0.0011	0.0017	0.0019
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.037	0.8958
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0016	0.0211	0.0237
Echinococcus multilocularis	neuropeptide receptor A26	0.0016	0.0211	0.0736
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0016	0.0211	0.0237
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.037	0.7482
Brugia malayi	AKH receptor	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	dro:myosuppressin receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0211	0.0211
Schistosoma mansoni	adenoreceptor	0.0016	0.0211	0.0237
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0242	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0021	0.0414	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	intermediate filament protein	0.0028	0.0718	0.2659
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0242	0.6545
Schistosoma mansoni	hypothetical protein	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.037	0.8958
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0103	0.0103
Echinococcus multilocularis	somatostatin receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0211	0.0237
Echinococcus multilocularis	GA binding protein alpha chain	0.0075	0.2652	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0021	0.0414	0.1505
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0211	0.0736
Brugia malayi	Dopamine receptor protein 2	0.0016	0.0211	0.0194
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0211	0.0736
Echinococcus granulosus	lamin dm0	0.0028	0.0718	0.2659
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	Ets-domain containing protein	0.0075	0.2652	0.2639
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	lamin	0.0028	0.0718	0.2659
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0211	0.0211
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0242	0.0226
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0211	0.0736
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0242	0.5863
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0242	0.0855
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0021	0.0414	0.1505
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0242	0.0855
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0211	0.0736
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0414	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	G protein coupled receptor 139	0.0016	0.0211	0.0736
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0112	0.4156	0.4156
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Brugia malayi	G-protein coupled receptor	0.0016	0.0211	0.0194
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0016	0.0211	0.0736
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0075	0.2652	0.2652
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0016	0.0211	0.0736
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Schistosoma mansoni	DNA helicase recq1	0.0021	0.0414	0.0463
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0211	0.0211
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0185	0.0168
Echinococcus granulosus	sex peptide receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	D-ets-2 protein	0.0011	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Echinococcus granulosus	neuropeptide s receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0242	0.0242
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0211	0.0736
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0016	0.0211	0.0736
Schistosoma mansoni	hypothetical protein	0.0016	0.0211	0.0237
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0211	0.0237
Schistosoma mansoni	hypothetical protein	0.0016	0.0211	0.0237
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0016	0.0211	0.0237
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.0211	0.0194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Schistosoma mansoni	opsin-like receptor	0.0016	0.0211	0.0237
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.0211	0.0194
Brugia malayi	neuropeptide F receptor	0.0016	0.0211	0.0194
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0718	0.0718
Brugia malayi	ORL1-like opioid receptor	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Schistosoma mansoni	histamine h1 receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0211	0.0736
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Schistosoma mansoni	ap endonuclease	0.002	0.037	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0718	0.0718
Schistosoma mansoni	ets-related	0.0229	0.8926	1
Echinococcus multilocularis	lamin dm0	0.0028	0.0718	0.2659
Schistosoma mansoni	lamin	0.0028	0.0718	0.0804
Schistosoma mansoni	DNA helicase recq5	0.0021	0.0414	0.0463
Schistosoma mansoni	amine GPCR	0.0016	0.0211	0.0237
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0021	0.0414	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0697	0.0697
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0121	0.4526	0.507
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	RE15519p	0.0016	0.0211	0.0194
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0011	0.0017	0.0017
Schistosoma mansoni	amine GPCR	0.0016	0.0211	0.0237
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0242	0.5863
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0017
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0242	0.0226
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0112	0.4156	0.4156
Schistosoma mansoni	gabp alpha	0.0075	0.2652	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	G protein-coupled receptor	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0121	0.4526	0.4526
Loa Loa (eye worm)	fli-1 protein	0.0229	0.8926	0.8926
Echinococcus granulosus	allatostatin A receptor	0.0016	0.0211	0.0736
Brugia malayi	Fli-1 protein	0.0229	0.8926	0.8924
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0021	0.0414	1
Brugia malayi	Serotonin receptor	0.0016	0.0211	0.0194
Echinococcus granulosus	somatostatin receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	opsin-like receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Onchocerca volvulus		0.0028	0.0718	1
Brugia malayi	neuropeptide F receptor	0.0016	0.0211	0.0194
Schistosoma mansoni	myosin xvIII	0.0016	0.0211	0.0237
Brugia malayi	Melatonin receptor type 1A	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0103	0.0103
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0211	0.0736
Schistosoma mansoni	neuropeptide f receptor 76f	0.0016	0.0211	0.0237
Echinococcus multilocularis	dro:myosuppressin receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0718	0.0718
Schistosoma mansoni	amine GPCR	0.0016	0.0211	0.0237
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0211	0.0736
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0414	1
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0414	0.0414
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0016	0.0211	0.0736
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.037	0.8958
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0414	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0016	0.0211	0.0736
Echinococcus multilocularis	musashi	0.0028	0.0718	0.2659
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0211	0.0237
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.037	0.1341
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0021	0.0414	0.0414
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0211	0.0211
Echinococcus granulosus	7TM GPCR rhodopsin	0.0016	0.0211	0.0736
Schistosoma mansoni	hypothetical protein	0.0054	0.1771	0.1984
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0211	0.0237
Echinococcus multilocularis	serotonin receptor	0.0016	0.0211	0.0736
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0414	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.037	0.037
Giardia lamblia	Sgs1 DNA helicase, putative	0.0021	0.0414	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0211	0.0237
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0016	0.0211	0.0736
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.0211	0.0194
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0121	0.4526	0.4526
Brugia malayi	hypothetical protein	0.0016	0.0211	0.0194
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0211	0.0736
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.0211	0.0194
Schistosoma mansoni	lamin	0.0028	0.0718	0.0804
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0242	0.5863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0414	0.0397
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.037	0.0354
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0016	0.0211	0.0736
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.0211	0.0194
Brugia malayi	Ets-domain containing protein	0.0075	0.2652	0.2639
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Schistosoma mansoni	hypothetical protein	0.0016	0.0211	0.0237
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0121	0.4526	0.4517
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0016	0.0211	0.0237
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0414	0.0397
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Schistosoma mansoni	ap endonuclease	0.002	0.037	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0242	0.0855
Schistosoma mansoni	ets-related	0.0011	0.0017	0.0019
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0414	0.0414
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.037	0.7482
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0016	0.0211	0.0736
Brugia malayi	Dopamine receptor protein 1	0.0016	0.0211	0.0194
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	allatostatin A receptor	0.0016	0.0211	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0124	0.0406
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0414	0.1505
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0211	0.0736
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Echinococcus granulosus	GA binding protein alpha chain	0.0075	0.2652	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0016	0.0211	0.0237
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0211	0.0736
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0242	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	sulfakinin receptor protein	0.0016	0.0211	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0016	0.0211	0.0237
Schistosoma mansoni	hypothetical protein	0.0011	0.0017	0.0019
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0242	0.0855
Schistosoma mansoni	opsin-like receptor	0.0016	0.0211	0.0237
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.037	0.5
Echinococcus multilocularis	sex peptide receptor	0.0016	0.0211	0.0736
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0211	0.0736
Brugia malayi	Serotonin receptor	0.0016	0.0211	0.0194
Brugia malayi	larval opioid receptor	0.0016	0.0211	0.0194
Brugia malayi	G-protein coupled receptor	0.0016	0.0211	0.0194
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0211	0.0736
Echinococcus granulosus	hypothetical protein	0.0016	0.0211	0.0736
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0242	0.0855
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0211	0.0736
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0414	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0016	0.0211	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Toxoplasma gondii	exonuclease III APE	0.002	0.037	0.8958
Onchocerca volvulus		0.0028	0.0718	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0211	0.0237
Echinococcus granulosus	neuropeptide receptor A26	0.0016	0.0211	0.0736
Schistosoma mansoni	elf1	0.0011	0.0017	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Brugia malayi	putative neuropeptide receptor	0.0016	0.0211	0.0194
Schistosoma mansoni	ets	0.0011	0.0017	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0211	0.0211

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.42 nM	Inhibition of PDE8B	ChEMBL.	21459572

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1780111

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1561465