Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | adenosine deaminase | 0.0327 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0327 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0327 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0306 | 0.8676 | 0.8676 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0327 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0327 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0327 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0327 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0327 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0327 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0327 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0327 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0327 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0327 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0327 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0327 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0306 | 0.8676 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0327 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0306 | 0.8676 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0327 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Cytotoxicity against human A549 cells by MTT assay | ChEMBL. | 21983438 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HCT116 cells by MTT assay | ChEMBL. | 21983438 |
IC50 (functional) | > 10 uM | Cytotoxicity against human NCI-H460 cells by MTT assay | ChEMBL. | 21983438 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21983438 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.