Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0262 | 0.2546 | 0.2546 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0482 | 0.5719 | 0.5719 |
Treponema pallidum | adenosine deaminase | 0.0262 | 0.2546 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0262 | 0.2546 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0779 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0779 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0262 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1316 | 0.1316 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0262 | 0.2546 | 0.0326 |
Leishmania major | adenine aminohydrolase | 0.0262 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1316 | 0.1316 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0482 | 0.5719 | 0.5719 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0482 | 0.5719 | 0.5719 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0779 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0779 | 1 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0262 | 0.2546 | 0.2546 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0779 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0779 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0482 | 0.5719 | 0.5719 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0262 | 0.2546 | 0.2546 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0779 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0779 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0262 | 0.2546 | 0.2546 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0779 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0779 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0779 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0262 | 0.2546 | 0.2546 |
Plasmodium falciparum | adenosine deaminase | 0.0262 | 0.2546 | 0.2546 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0779 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0262 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1316 | 0.1316 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0779 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0779 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2546 | 0.2546 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0779 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0262 | 0.2546 | 0.2546 |
Schistosoma mansoni | adenosine deaminase | 0.0262 | 0.2546 | 0.2546 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0262 | 0.2546 | 0.0326 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0779 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0779 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0262 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1316 | 0.1316 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0779 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC30 (functional) | = 0.42 uM | Induction of mitotic arrest in human HT-29 cells assessed as increase in p-histone H3 level after 24 hrs by immunostaining | ChEMBL. | 22070629 |
LD50 (functional) | = 1.2 uM | Antiproliferative activity against human HT-29 cells after 72 hrs by luminescence assay | ChEMBL. | 22070629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.