TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 284.313 | Formula: C15H16N4O2
H donors: 2 H acceptors: 4 LogP: 1.91 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(Cn1c(=O)[nH]c2c1nc(cn2)c1ccc(cc1)O)C
InChi: 1S/C15H16N4O2/c1-9(2)8-19-14-13(18-15(19)21)16-7-12(17-14)10-3-5-11(20)6-4-10/h3-7,9,20H,8H2,1-2H3,(H,16,18,21)
InChiKey: FMIYVWZLZNGVQL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.3768	0.8002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.2081	0.4418
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0743	0.0326
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0743	0.0423
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0743	0.0337
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.3392	0.7204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.2119	0.4499
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1748	0.3713
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Brugia malayi	nuclear hormone receptor	0.0021	0.0743	0.0326
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.4709	0.447
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0099	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0946	0.1204
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0743	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.4709	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1743	0.3702
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0743	0.0337
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.4709	0.447
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.1317	0.207
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.2119	0.4499
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0743	0.0326
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0099	1	1
Brugia malayi	hypothetical protein	0.0078	0.7482	0.7368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0431	0.0916
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0743	0.0423
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.4709	1
Schistosoma mansoni	jun-related protein	0.008	0.7803	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0743	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0743	0.0326
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0743	0.0326
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0743	0.0326
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0743	0.0326
Giardia lamblia	GTOR	0.0054	0.4709	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.3392	0.7204
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0743	0.0326
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.3397	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.259	0.5501
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0743	0.0337
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0743	0.0423
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.4709	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0743	0.0326
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0743	0.0326
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0743	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0096	0.9679	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.2451	0.5205
Brugia malayi	steroid hormone receptor	0.0021	0.0743	0.0326
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.3397	0.6934
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0743	0.0326
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0743	0.0337
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0743	0.0326
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0743	0.0326
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0743	0.0326
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0743	0.0326
Echinococcus granulosus	jun protein	0.0099	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0743	0.0326
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.4709	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0431	0.0916
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0743	0.0423
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0743	0.0326
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.4709	0.5802
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.306	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1748	0.3713
Schistosoma mansoni	hypothetical protein	0.008	0.7803	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.4709	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.4709	0.4625
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0743	0.0326
Onchocerca volvulus		0.0078	0.7482	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0743	0.0326
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0743	0.0337
Schistosoma mansoni	coup transcription factor	0.0021	0.0743	0.0423
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0743	0.0423
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.3392	0.7204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.4709	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Brugia malayi	ecdysteroid receptor	0.0021	0.0743	0.0326
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1748	0.3713
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0743	0.0423
Echinococcus multilocularis	jun protein	0.0099	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0743	0.0326
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0743	0.0326
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.4709	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.4709	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0743	0.0326
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.2081	0.4418
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.3397	0.6934
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.2119	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0431	0.0916
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1743	0.3702
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0743	0.0326
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0743	0.0326
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0743	0.0326
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0743	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0743	0.0337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0431	0.0916
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1748	0.3713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.3392	0.7204
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0743	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.3392	0.7204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0431	0.0916
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.4709	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1743	0.3702
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.4709	0.447
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0743	0.0337
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.4709	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0743	0.0423
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0743	0.0326
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0743	0.0423
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0743	0.0326
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0743	0.0337
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.4709	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.306	0.6498
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0743	0.0423

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.02 uM	Inhibition of mTOR	ChEMBL.	21978683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1945788

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1564568