Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0097 | 0.0573 | 0.1879 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0272 | 0.3052 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0272 | 0.3052 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0097 | 0.0573 | 0.1879 |
Schistosoma mansoni | brg-1 associated factor | 0.0272 | 0.3052 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0097 | 0.0573 | 0.1879 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0097 | 0.0573 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0097 | 0.0573 | 0.1879 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0112 | 0.0785 | 0.0853 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.3052 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0573 | 0.1879 |
Brugia malayi | brahma associated protein 60 kDa | 0.0272 | 0.3052 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0573 | 0.1879 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0573 | 0.1879 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0097 | 0.0573 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0785 | 0.2572 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0272 | 0.3052 | 0.263 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.3052 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0272 | 0.3052 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0097 | 0.0573 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0097 | 0.0573 | 0.1879 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0573 | 0.1879 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.3052 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0272 | 0.3052 | 0.263 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0097 | 0.0573 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0272 | 0.3052 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0097 | 0.0573 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0097 | 0.0573 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0272 | 0.3052 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0272 | 0.3052 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Onchocerca volvulus | 0.0112 | 0.0785 | 0.0853 | |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0272 | 0.3052 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0097 | 0.0573 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0097 | 0.0573 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0272 | 0.3052 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0272 | 0.3052 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0272 | 0.3052 | 0.263 |
Leishmania major | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0097 | 0.0573 | 1 |
Onchocerca volvulus | 0.0272 | 0.3052 | 1 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0272 | 0.3052 | 0.263 |
Echinococcus multilocularis | tumor protein p63 | 0.0763 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.3052 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0272 | 0.3052 | 0.263 |
Leishmania major | hypothetical protein, conserved | 0.0097 | 0.0573 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0272 | 0.3052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0573 | 0.1879 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0272 | 0.3052 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0272 | 0.3052 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0272 | 0.3052 | 0.263 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 100 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by ten-fold serial dilution method | ChEMBL. | 22128803 |
MIC99 (functional) | > 50 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by ten-fold serial dilution method | ChEMBL. | 22128803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.