Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4A, cAMP-specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1242 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1242 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Giardia lamblia | Serine peptidase, putative | 0.0271 | 0.1307 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0482 | 0.3192 | 0.3192 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0271 | 0.1307 | 0.1307 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0271 | 0.1307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1307 | 0.1307 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0271 | 0.1307 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.1242 | 1 | 1 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0271 | 0.1307 | 0.5 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.0271 | 0.1307 | 0.5 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.1242 | 1 | 1 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.0271 | 0.1307 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0271 | 0.1307 | 0.5 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.0271 | 0.1307 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.1242 | 1 | 1 |
Onchocerca volvulus | 0.0271 | 0.1307 | 0.5 | |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0271 | 0.1307 | 0.1307 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0482 | 0.3192 | 0.3192 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0271 | 0.1307 | 0.1307 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1242 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0271 | 0.1307 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | Inhibition of human recombinant PDE7A1 expressed in baculovirus infected insect Sf21 cells after 30 mins by scintillation proximity assay | ChEMBL. | 21983442 |
IC50 (binding) | > 1 uM | Inhibition of human recombinant PDE4A4 expressed in baculovirus infected insect Sf21 cells after 30 mins by scintillation proximity assay | ChEMBL. | 21983442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.