Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | jun protein | 0.0094 | 0.3888 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0076 | 0.0496 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 1 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0094 | 0.3888 | 0.3888 |
Echinococcus granulosus | jun protein | 0.0094 | 0.3888 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0094 | 0.3888 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.9382 | 0.9065 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.9382 | 0.9065 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.9382 | 0.9382 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0496 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0094 | 0.3888 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.