Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | 0.0244 | 1 | 1 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0076 | 0.1937 | 0.5 |
Onchocerca volvulus | 0.0235 | 0.9573 | 1 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 0.9573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.9554 | 1 |
Brugia malayi | hypothetical protein | 0.0235 | 0.9554 | 1 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0076 | 0.1937 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0584 | 0.3015 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 0.9554 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.8203 | 0.8586 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.1937 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.8203 | 0.8227 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0584 | 0.0611 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0076 | 0.1937 | 0.2027 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0076 | 0.1937 | 0.2027 |
Trypanosoma brucei | squalene synthase, putative | 0.0244 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0076 | 0.1937 | 0.1505 |
Trypanosoma cruzi | squalene synthase, putative | 0.0244 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 0.9554 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0584 | 0.3015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Inhibition of CYP2A6 in human liver microsomes assessed as inhibition of coumarin 7-hydroxylation after 10 mins by plate reader | ChEMBL. | 22019468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.