Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.002 | 0.0057 | 0.0441 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0272 | 0.3217 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0057 | 0.0057 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0057 | 0.0068 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0057 | 0.0068 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0057 | 0.0068 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0057 | 0.0441 |
Plasmodium vivax | LCCL domain-containing protein | 0.0272 | 0.3217 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0057 | 0.0068 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0023 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0682 | 0.8368 | 0.8368 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0057 | 0.0068 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0003 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0423 | 0.3289 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0423 | 0.3289 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0057 | 0.0441 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.0057 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0057 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0057 | 0.0441 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1286 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0057 | 0.0441 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0423 | 0.3289 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.3217 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0003 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0057 | 0.0057 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0057 | 0.0441 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0057 | 0.0441 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0057 | 0.0068 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0003 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0057 | 0.0068 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0057 | 0.0441 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0057 | 0.0068 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.3217 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0057 | 0.0068 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0003 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0057 | 0.0068 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0057 | 0.0068 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0057 | 0.0068 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0023 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0057 | 0.0441 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0057 | 0.0057 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0003 | 0.0003 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0057 | 0.0068 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.3217 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0227 | 0.1767 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0003 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0057 | 0.0441 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0272 | 0.3217 | 1 |
Trichomonas vaginalis | Antigenic protein P1, putative | 0.0272 | 0.3217 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.3217 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0003 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0057 | 0.0441 |
Toxoplasma gondii | PA14 domain-containing protein | 0.0272 | 0.3217 | 1 |
Plasmodium vivax | LCCL domain-containing protein | 0.0272 | 0.3217 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0057 | 0.0057 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0682 | 0.8368 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0057 | 0.0441 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0057 | 0.0057 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0057 | 0.0068 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0057 | 0.0057 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0057 | 0.0441 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0003 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0682 | 0.8368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0227 | 0.1767 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0057 | 0.0057 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0057 | 0.0068 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0057 | 0.0068 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0057 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0057 | 0.0068 |
Toxoplasma gondii | PA14 domain-containing protein | 0.0272 | 0.3217 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0003 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0057 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0057 | 0.0441 |
Toxoplasma gondii | PA14 domain-containing protein | 0.0272 | 0.3217 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1286 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0057 | 0.0441 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0003 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0057 | 0.0068 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0057 | 0.0441 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0057 | 0.0068 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0423 | 0.3289 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0057 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0003 | 0.0023 |
Onchocerca volvulus | 0.002 | 0.0057 | 0.5 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0057 | 0.0068 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0057 | 0.0441 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0057 | 0.0441 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0227 | 0.0271 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0003 | 0.5 |
Plasmodium vivax | LCCL domain-containing protein | 0.0272 | 0.3217 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1286 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0057 | 0.0441 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0057 | 0.0441 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0057 | 0.0068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.