Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.9122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.9122 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.9122 | 0.5 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0064 | 0.1022 | 0.0596 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0098 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0098 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.908 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0098 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0064 | 0.1022 | 0.0596 |
Onchocerca volvulus | Netrin receptor homolog | 0.0064 | 0.1022 | 0.5 |
Brugia malayi | Death domain containing protein | 0.0064 | 0.1022 | 0.112 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0098 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.1022 | 0.112 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0064 | 0.1022 | 0.0596 |
Brugia malayi | Uncoordinated protein 44 | 0.0064 | 0.1022 | 0.112 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.908 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.0453 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0064 | 0.1022 | 0.0596 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.0453 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1022 | 0.112 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0.9122 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.9122 | 0.9022 |
Echinococcus granulosus | death domain containing protein | 0.0064 | 0.1022 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1022 | 0.112 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0064 | 0.1022 | 0.112 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.9122 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0064 | 0.1022 | 0.112 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.9122 | 0.5 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0064 | 0.1022 | 0.0596 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0064 | 0.1022 | 0.0596 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.9122 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.