Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.4832 | 0.4832 |
Toxoplasma gondii | ion channel protein | 0.0015 | 0.0141 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | TWiK family of potassium channels protein 7 | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0307 | 1 | 1 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 21 | 0.0015 | 0.0141 | 0.1578 |
Echinococcus granulosus | twik family of potassium channels | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.0015 | 0.0141 | 0.0141 |
Plasmodium falciparum | potassium channel | 0.0015 | 0.0141 | 0.5 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0015 | 0.0141 | 0.5 |
Echinococcus multilocularis | twik family of potassium channels | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 12 | 0.0015 | 0.0141 | 0.1578 |
Loa Loa (eye worm) | TWK-7 protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0015 | 0.0141 | 0.5 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0015 | 0.0141 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.005 | 0.1316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0727 | 0.0727 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.005 | 0.1316 | 1 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0141 | 0.1578 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0015 | 0.0141 | 0.1578 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0292 | 0.9495 | 0.9495 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | potassium channel subfamily K | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | twik family of potassium channels | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | TWK-28 protein | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma cruzi | ion transport protein, putative | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0307 | 1 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog | 0.0015 | 0.0141 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Brugia malayi | Twik (KCNK-like) family of potasium channels, alpha subunit 40 | 0.0015 | 0.0141 | 0.1578 |
Loa Loa (eye worm) | S-phase kinase-associated protein 1A | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0015 | 0.0141 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.002 | 0.0307 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.1009 | 0.1009 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0015 | 0.0141 | 0.1578 |
Giardia lamblia | Hypothetical protein | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog | 0.0015 | 0.0141 | 0.1578 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0015 | 0.0141 | 0.0141 |
Leishmania major | ion transport protein-like protein | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0893 | 0.0893 |
Plasmodium vivax | potassium channel, putative | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 13 | 0.0015 | 0.0141 | 0.1578 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.1009 | 0.1009 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0015 | 0.0141 | 0.0141 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0015 | 0.0141 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 5 | 0.0015 | 0.0141 | 0.1578 |
Echinococcus granulosus | TWiK family of potassium channels protein 7 | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 45 | 0.0015 | 0.0141 | 0.1578 |
Echinococcus granulosus | twik family of potassium channels | 0.0015 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0141 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0893 | 1 |
Echinococcus granulosus | potassium channel subfamily K | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0015 | 0.0141 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0893 | 0.0893 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 7 | 0.0015 | 0.0141 | 0.1578 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39B | 0.0015 | 0.0141 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0893 | 0.0893 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0015 | 0.0141 | 0.0141 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0015 | 0.0141 | 0.0141 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Trypanosoma cruzi | ion transport protein, putative | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 24 | 0.0015 | 0.0141 | 0.1578 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 35 | 0.0015 | 0.0141 | 0.1578 |
Plasmodium vivax | potassium channel, putative | 0.0015 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Mycobacterium ulcerans | ion transport protein | 0.0015 | 0.0141 | 0.5 |
Plasmodium falciparum | potassium channel | 0.0015 | 0.0141 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0015 | 0.0141 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39A | 0.0015 | 0.0141 | 0.1578 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4299 | 0.4299 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0015 | 0.0141 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0015 | 0.0141 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.002 | 0.0307 | 0.1414 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0015 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | uncoordinated protein 58 | 0.0015 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0015 | 0.0141 | 0.5 | |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 28 | 0.0015 | 0.0141 | 0.1578 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 17 | 0.0015 | 0.0141 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0141 | 0.0141 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.007 ug ml-1 | Minimum inhibitory concentration of the compound against S. pyogenes 308A was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against S. aureus 503 was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against E. coli 055 was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against E. coli 1507E was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against S. typhimurium was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against E. cloacae 1321E was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against E. coli 055 was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.025 ug ml-1 | Minimum inhibitory concentration of the compound against E. coli 1507E was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.049 ug ml-1 | Minimum inhibitory concentration of the compound against S. aureus SG 511 was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.049 ug ml-1 | Minimum inhibitory concentration of the compound against S. aureus 285 was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.049 ug ml-1 | Minimum inhibitory concentration of the compound against K. aerogenes 1522E was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.098 ug ml-1 | Minimum inhibitory concentration of the compound against P. aeruginosa 9027 was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.098 ug ml-1 | Minimum inhibitory concentration of the compound against P. aeruginosa 1771M was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.195 ug ml-1 | Minimum inhibitory concentration of the compound against P. aeruginosa 1592E was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
MIC (functional) | = 0.195 ug ml-1 | Minimum inhibitory concentration of the compound against P. aeruginosa 1771M was determined by agar dilution method using Mueller-Hinton | ChEMBL. | 11133095 |
Relativity (functional) | = 2.68 | Relative half life of hydrolosis of the compound to meropenem by partially purified porcine renal DHP-I was determined | ChEMBL. | 11133095 |
Relativity (functional) | = 1.35 | Relative half life of hydrolosis of the compound to meropenem by partially purified porcine renal DHP-I was determined | ChEMBL. | 11133095 |
Relativity (functional) | = 2.68 | Relative half life of hydrolosis of the compound to meropenem by partially purified porcine renal DHP-I was determined | ChEMBL. | 11133095 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.