Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0242 | 1 | 1 |
Echinococcus granulosus | death domain containing protein | 0.0159 | 0.6257 | 0.6257 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0159 | 0.6257 | 0.6257 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0242 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.051 | 0.0815 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0159 | 0.6257 | 0.6257 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.6257 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0159 | 0.6257 | 0.6257 |
Echinococcus multilocularis | Ankyrin | 0.0159 | 0.6257 | 0.6257 |
Brugia malayi | Uncoordinated protein 44 | 0.0159 | 0.6257 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.6257 | 0.6257 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0159 | 0.6257 | 1 |
Echinococcus granulosus | Ankyrin | 0.0159 | 0.6257 | 0.6257 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.051 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0159 | 0.6257 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0159 | 0.6257 | 1 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0242 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.051 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.051 | 1 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0242 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.051 | 1 |
Brugia malayi | Death domain containing protein | 0.0159 | 0.6257 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0159 | 0.6257 | 0.6257 |
Onchocerca volvulus | Netrin receptor homolog | 0.0159 | 0.6257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.051 | 0.0815 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0159 | 0.6257 | 0.6257 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.051 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.051 | 1 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0159 | 0.6257 | 0.6257 |
Schistosoma mansoni | netrin receptor unc5 | 0.0159 | 0.6257 | 0.6257 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.051 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0026 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.6257 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.051 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.