Detailed information for compound 1570886
Basic information
Technical information
- Name: Unnamed compound
- MW: 697.128 | Formula: C35H37ClN2O11
-
H donors: 5
H acceptors: 6
LogP: 5.33
Rotable bonds: 11
Rule of 5 violations (Lipinski): 2 - SMILES: COC1C(OC(=O)c2ccc([nH]2)C)C(O)C(OC1(C)C)Oc1ccc2c(c1Cl)oc(=O)c(c2O)NC(=O)c1ccc(c(c1)CC=C(C)C)O
- InChi: 1S/C35H37ClN2O11/c1-16(2)7-9-18-15-19(10-13-22(18)39)31(42)38-25-26(40)20-11-14-23(24(36)28(20)47-33(25)44)46-34-27(41)29(30(45-6)35(4,5)49-34)48-32(43)21-12-8-17(3)37-21/h7-8,10-15,27,29-30,34,37,39-41H,9H2,1-6H3,(H,38,42)
- InChiKey: FJAQNRBDVKIIKK-UHFFFAOYSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | runt-related transcription factor 1 | Starlite/ChEMBL | No references |
| Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
| Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
| Trypanosoma brucei gambiense | UDP-galactose 4-epimerase, putative | References | |
| Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
| Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
| Human immunodeficiency virus 1 | Envelope glycoprotein gp160 | Starlite/ChEMBL | No references |
| Homo sapiens | core-binding factor, beta subunit | No references | |
| Trypanosoma brucei | UDP-galactose 4-epimerase | Starlite/ChEMBL | References |
| Staphylococcus aureus (strain N315) | Probable nicotinate-nucleotide adenylyltransferase | Starlite/ChEMBL | No references |
| Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
| Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0069 | 0.0446 | 0.0574 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0092 | 0.0117 |
| Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0102 | 0.0162 |
| Toxoplasma gondii | UDP-glucose 4-epimerase | 0.012 | 0.1092 | 0.2911 |
| Leishmania major | udp-glc 4-epimerase, putative | 0.0125 | 0.1154 | 1 |
| Schistosoma mansoni | lozenge | 0.0067 | 0.0426 | 0.0337 |
| Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.1104 | 0.9536 |
| Treponema pallidum | hypothetical protein | 0.0345 | 0.3893 | 1 |
| Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0345 | 0.3893 | 1 |
| Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.1498 | 0.4208 |
| Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.1104 | 0.9536 |
| Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0058 | 0.031 | 0.2246 |
| Trichomonas vaginalis | rotamase, putative | 0.004 | 0.0092 | 0.0117 |
| Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0069 | 0.0446 | 0.0574 |
| Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.012 | 0.1092 | 0.9887 |
| Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.034 | 0.0402 |
| Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.0426 | 0.0337 |
| Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.034 | 0.0542 |
| Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0345 | 0.3893 | 1 |
| Echinococcus multilocularis | neuropeptide s receptor | 0.0558 | 0.6565 | 0.6533 |
| Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.1498 | 0.305 |
| Chlamydia trachomatis | DNA gyrase subunit A | 0.0318 | 0.3559 | 1 |
| Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.012 | 0.1092 | 0.9887 |
| Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 0.3559 | 0.8605 |
| Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.012 | 0.1092 | 1 |
| Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0058 | 0.031 | 0.2142 |
| Schistosoma mansoni | DNA topoisomerase II | 0.0069 | 0.0446 | 0.0358 |
| Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
| Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.012 | 0.1092 | 1 |
| Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0446 | 0.362 |
| Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.012 | 0.1092 | 1 |
| Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 0.3559 | 0.9031 |
| Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0345 | 0.3893 | 1 |
| Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 0.3559 | 0.8605 |
| Echinococcus multilocularis | UDP glucose 4 epimerase | 0.012 | 0.1092 | 0.101 |
| Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0058 | 0.031 | 0.2142 |
| Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.034 | 0.0542 |
| Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 0.3559 | 1 |
| Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.1481 | 0.3387 |
| Brugia malayi | hypothetical protein | 0.0535 | 0.6271 | 1 |
| Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.0692 | 0.1759 |
| Echinococcus granulosus | UDP glucose 4 epimerase | 0.012 | 0.1092 | 0.101 |
| Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0102 | 0.001 |
| Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 0.3559 | 0.9031 |
| Brugia malayi | Probable DNA topoisomerase II | 0.0069 | 0.0446 | 0.0574 |
| Leishmania major | DNA topoisomerase ii | 0.0058 | 0.031 | 0.2142 |
| Chlamydia trachomatis | DNA gyrase subunit B | 0.01 | 0.084 | 0.236 |
| Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.1104 | 1 |
| Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0069 | 0.0446 | 0.0358 |
| Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.1498 | 0.305 |
| Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.6271 | 1 |
| Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 0.3559 | 0.8605 |
| Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.0446 | 0.362 |
| Giardia lamblia | UDP-glucose 4-epimerase | 0.0125 | 0.1154 | 1 |
| Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0345 | 0.3893 | 1 |
| Loa Loa (eye worm) | TOPoisomerase family member | 0.0069 | 0.0446 | 0.0712 |
| Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.6271 | 1 |
| Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0345 | 0.3893 | 1 |
| Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0102 | 0.0017 |
| Echinococcus granulosus | neuropeptide s receptor | 0.0558 | 0.6565 | 0.6533 |
| Loa Loa (eye worm) | runx1 | 0.0067 | 0.0426 | 0.0679 |
| Onchocerca volvulus | 0.0535 | 0.6271 | 1 | |
| Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0069 | 0.0446 | 0.0358 |
| Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
| Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 0.0092 | 0.0146 |
| Schistosoma mansoni | UDP-glucose 4-epimerase | 0.012 | 0.1092 | 0.101 |
| Echinococcus multilocularis | neuropeptide receptor A26 | 0.0558 | 0.6565 | 0.6533 |
| Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.1104 | 1 |
| Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 0.3559 | 1 |
| Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0125 | 0.1154 | 1 |
| Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0058 | 0.031 | 0.2246 |
| Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0069 | 0.0446 | 0.1054 |
| Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.012 | 0.1092 | 1 |
| Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.034 | 0.0402 |
| Echinococcus granulosus | neuropeptide receptor A26 | 0.0558 | 0.6565 | 0.6533 |
| Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.012 | 0.1092 | 0.1742 |
| Brugia malayi | UDP galactose 4'-epimerase | 0.012 | 0.1092 | 0.162 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| EC50 (functional) | = 4.4 uM | Antitrypanosomal activity against Trypanosoma brucei after 3 days by alamar blue assay | ChEMBL. | 20527952 |
| EC50 (ADMET) | > 50 uM | Cytotoxicity against human MRC5 cells after 3 days by alamar blue assay | ChEMBL. | 20527952 |
| GI50 (functional) | -4.745 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.705 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.696 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.684 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.638 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.58 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.508 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -4.417 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| IC50 (functional) | 2.1 uM | PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
| IC50 (binding) | = 5 uM | Inhibition of hexahistidine-tagged Trypanosoma brucei UDP-galactose-4'epimerase expressed in Escherichia coli | ChEMBL. | 20527952 |
| IC50 (functional) | 7.01 uM | PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
| IC50 (binding) | = 13 uM | PUBCHEM_BIOASSAY: uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1991, AID434967] | ChEMBL. | No reference |
| IC50 (functional) | 41.9 uM | PubChem BioAssay. Identify HuR specific inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 11.5821 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (binding) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] | ChEMBL. | No reference |
| Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
| Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
| Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
| Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
| Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
| Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
| Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
| Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
| Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
| Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
| Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
| Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
| Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1477, AID1484] | ChEMBL. | No reference |
| Potency (functional) | 562.3413 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Homo sapiens | ChEMBL23 | ||
| Trypanosoma brucei | ChEMBL23 | 20527952 | |
| Plasmodium falciparum | ChEMBL23 | ||
| Trypanosoma brucei gambiense | 20527952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1172192
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.