Detailed information for compound 1570997

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 390.432 | Formula: C16H35Cl2N2O2S+
  • H donors: 0 H acceptors: 2 LogP: 3.8 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClN(C(CCS(=O)(=O)CCCCCCCC[N+](C)(C)C)(C)C)Cl
  • InChi: 1S/C16H35Cl2N2O2S/c1-16(2,19(17)18)12-15-23(21,22)14-11-9-7-6-8-10-13-20(3,4)5/h6-15H2,1-5H3/q+1
  • InChiKey: SXVFCPNZPAVGOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0141 0.0519 0.2384
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0032 0.0078
Mycobacterium ulcerans DNA topoisomerase I 0.0141 0.0519 0.0519
Trypanosoma cruzi Heat shock protein 83, putative 0.0062 0.0109 0.0191
Echinococcus multilocularis nAChR subunit 0.0117 0.0397 0.0978
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0109 0.0501
Leishmania major hypothetical protein, conserved 0.0062 0.0109 0.0191
Trypanosoma brucei DNA topoisomerase II beta, putative 0.032 0.1445 0.2539
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.023 0.0568
Onchocerca volvulus 0.0054 0.0069 0.0318
Echinococcus granulosus glycine receptor subunit alpha 1 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0141 0.0519 0.2384
Echinococcus multilocularis nAChR subunit 0.0063 0.0116 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0116 0.0534
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0397 0.1824
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0054 0.0069 0.0318
Leishmania major developmentally regulated phosphoprotein-like protein 0.0062 0.0109 0.0191
Schistosoma mansoni endoplasmin 0.0062 0.0109 0.0501
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0117 0.0397 0.1824
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0117 0.0397 0.1824
Loa Loa (eye worm) ACC-1 protein 0.0117 0.0397 0.1824
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0054 0.0069 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0125 0.0576
Mycobacterium leprae Probable two component sensor kinase MprB 0.0062 0.0109 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1161 0.5338
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0461 0.2175 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0062 0.0109 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Onchocerca volvulus 0.0063 0.0116 0.0534
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Mycobacterium tuberculosis Conserved protein 0.0062 0.0109 0.0109
Entamoeba histolytica DNA topoisomerase II, putative 0.0461 0.2175 1
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0062 0.0109 0.0501
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0397 0.1824
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1972 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1161 0.5338
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0069 0.0318
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0117 0.0397 0.1824
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0062 0.0109 0.0109
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Trichomonas vaginalis DNA topoisomerase II, putative 0.0461 0.2175 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0062 0.0109 0.0501
Schistosoma mansoni DNA topoisomerase II 0.0461 0.2175 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0117 0.0397 0.1824
Onchocerca volvulus 0.0085 0.023 0.1059
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0116 0.0534
Leishmania major mitochondrial DNA topoisomerase II 0.114 0.5691 1
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Leishmania major DNA topoisomerase 1A 0.0141 0.0519 0.0911
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.0109 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0032 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1161 0.5338
Echinococcus granulosus tar DNA binding protein 0.0065 0.0125 0.0576
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0117 0.0397 0.0978
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0117 0.0397 0.0978
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0062 0.0109 0.0501
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0117 0.0397 0.0978
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0461 0.2175 1
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Brugia malayi RNA binding protein 0.0065 0.0125 0.0576
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0318 0.1462
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) LGC-31 protein 0.0117 0.0397 0.1824
Onchocerca volvulus 0.0054 0.0069 0.0318
Schistosoma mansoni heat shock protein 0.0062 0.0109 0.0501
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0117 0.0397 0.1824
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0111 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0125 0.0576
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0125 0.0309
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0111 0.0511
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Schistosoma mansoni nAChR subunit 0.0054 0.0069 0.0318
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Brugia malayi Cation transporter family protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Trypanosoma cruzi DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Schistosoma mansoni neurotransmitter gated ion channel 0.0054 0.0069 0.0318
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Trypanosoma cruzi DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0062 0.0109 0.0109
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0895 0.4113
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0117 0.0397 0.1824
Trypanosoma brucei DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Brugia malayi hypothetical protein 0.0054 0.0069 0.0318
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) acetylcholine receptor protein 0.0054 0.0069 0.0318
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.023 0.1059
Onchocerca volvulus 0.0117 0.0397 0.1824
Schistosoma mansoni heat shock protein 0.0062 0.0109 0.0501
Onchocerca volvulus 0.0243 0.1047 0.4816
Trypanosoma cruzi heat shock protein 85, putative 0.0062 0.0109 0.0191
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0062 0.0109 0.0109
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.0109 0.0191
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0679 0.3304 1
Plasmodium falciparum DNA topoisomerase 3, putative 0.0141 0.0519 0.0414
Brugia malayi hypothetical protein 0.0054 0.0069 0.0318
Loa Loa (eye worm) TOPoisomerase family member 0.0461 0.2175 1
Trypanosoma brucei DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Mycobacterium leprae Probable two-component sensor kinase 0.0062 0.0109 0.033
Onchocerca volvulus 0.0336 0.1529 0.7031
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0117 0.0397 0.1824
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0738 0.3391
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0111 0.0274
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0062 0.0109 0.0501
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0062 0.0109 0.0109
Echinococcus granulosus nAChR subunit 0.0117 0.0397 0.1824
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0318 0.1462
Trypanosoma brucei DNA topoisomerase ii 0.114 0.5691 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0062 0.0109 0.0501
Plasmodium vivax heat shock protein 86, putative 0.0062 0.0109 0.0109
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0117 0.0397 0.1824
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0054 0.0069 0.0318
Trypanosoma cruzi DNA topoisomerase II, putative 0.032 0.1445 0.2539
Onchocerca volvulus 0.0117 0.0397 0.1824
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.4055 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0117 0.0397 0.0978
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.114 0.5691 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0117 0.0397 0.1824
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0062 0.0109 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0032 0.0145
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0062 0.0109 0.0109
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0117 0.0397 0.1824
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Onchocerca volvulus 0.0117 0.0397 0.1824
Echinococcus granulosus glycine receptor subunit beta 0.0117 0.0397 0.1824
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0062 0.0109 0.0191
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0117 0.0397 0.1824
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0117 0.0397 0.1824
Onchocerca volvulus 0.0336 0.1529 0.7031
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0117 0.0397 0.0978
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0141 0.0519 0.2384
Schistosoma mansoni acetylcholine receptor-related 0.0054 0.0069 0.0318
Echinococcus multilocularis glycine receptor subunit beta 0.0117 0.0397 0.0978
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0117 0.0397 0.1824
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Trichomonas vaginalis receptor histidine kinase, putative 0.0062 0.0109 0.0501
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Chlamydia trachomatis DNA topoisomerase I 0.0141 0.0519 0.0414
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0111 0.0111
Loa Loa (eye worm) DNA topoisomerase III 0.0141 0.0519 0.2384
Loa Loa (eye worm) endoplasmin 0.0062 0.0109 0.0501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0318 0.1462
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1161 0.5338
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.015 0.0692
Echinococcus granulosus glycine receptor subunit alpha 1 0.0117 0.0397 0.1824
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0063 0.0116 0.0534
Leishmania major DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0125 0.0576
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0397 0.1824
Echinococcus multilocularis heat shock protein 90 0.0062 0.0109 0.0269
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0062 0.0109 0.0109
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0141 0.0519 0.2384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.114 0.114
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0085 0.023 0.1059
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0062 0.0109 0.033
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0117 0.0397 0.1824
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0461 0.2175 0.5364
Schistosoma mansoni neurotransmitter gated ion channel 0.0054 0.0069 0.0318
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.1161 0.5338
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0117 0.0397 0.1824
Brugia malayi excitatory GABA receptor EXP-1A 0.0117 0.0397 0.1824
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0111 0.0111
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0117 0.0397 0.0978
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0111 0.0511
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0062 0.0109 0.0501
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0125 0.0576
Plasmodium vivax DNA topoisomerase 3, putative 0.0141 0.0519 0.0519
Brugia malayi hypothetical protein 0.0054 0.0069 0.0318
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0111 0.0111
Treponema pallidum DNA topoisomerase I (topA) 0.0141 0.0519 0.0414
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0117 0.0397 0.1824
Giardia lamblia DNA topoisomerase II 0.0399 0.1854 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0117 0.0397 0.0978
Brugia malayi heat shock protein 90 0.0062 0.0109 0.0501
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0032 0.0145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0032 0.0145
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0141 0.0519 0.2384
Trichomonas vaginalis sensor histidine kinase, putative 0.0062 0.0109 0.0501
Onchocerca volvulus Putative nachr subunit 0.0117 0.0397 0.1824
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0062 0.0109 0.0109
Schistosoma mansoni neurotransmitter gated ion channel 0.0063 0.0116 0.0534
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0054 0.0069 0.0318
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0336 0.1529 0.7031
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0054 0.0069 0.0318
Mycobacterium ulcerans putative regultory protein 0.0062 0.0109 0.0109
Giardia lamblia DNA topoisomerase III 0.0141 0.0519 0.2347
Brugia malayi hypothetical protein 0.0054 0.0069 0.0318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0032 0.0145
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0062 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0062 0.0109 0.0109
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0063 0.0116 0.0534
Mycobacterium ulcerans DNA gyrase subunit B 0.1972 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0738 0.3391
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1047 0.4816
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0032 0.0145
Loa Loa (eye worm) hypothetical protein 0.0282 0.1249 0.5741
Schistosoma mansoni endoplasmin 0.0062 0.0109 0.0501
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0117 0.0397 0.0978
Toxoplasma gondii DNA topoisomerase 2, putative 0.0461 0.2175 0.3822
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0125 0.0576
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0117 0.0397 0.1824
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0689 0.3168
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.032 0.1445 0.2539
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Trypanosoma cruzi heat shock protein 85, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.032 0.1445 0.6643
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0461 0.2175 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0125 0.0576
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Brugia malayi Pre-SET motif family protein 0.0214 0.0895 0.4113
Plasmodium vivax endoplasmin, putative 0.0062 0.0109 0.0109
Mycobacterium ulcerans two component regulator - sensor kinase 0.0062 0.0109 0.0109
Brugia malayi GRF zinc finger family protein 0.0141 0.0519 0.2384
Leishmania major DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0397 0.1824
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0117 0.0397 0.1824
Echinococcus granulosus nAChR subunit 0.0063 0.0116 0.0534
Trichomonas vaginalis receptor histidine kinase, putative 0.0062 0.0109 0.0501
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0062 0.0109 0.0109
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0461 0.2175 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0062 0.0109 0.0109
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0117 0.0397 0.0978
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.023 0.1059
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0062 0.0109 0.0109
Onchocerca volvulus 0.0063 0.0116 0.0534
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0062 0.0109 0.0109
Brugia malayi Cation transporter family protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0117 0.0397 0.1824
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0117 0.0397 0.1824
Toxoplasma gondii heat shock protein 90, putative 0.0062 0.0109 0.0191
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0125 0.0576
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Mycobacterium ulcerans two component sensor kinase MprB 0.0062 0.0109 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0111 0.0511
Schistosoma mansoni pyruvate dehydrogenase 0.0062 0.0109 0.0501
Loa Loa (eye worm) hypothetical protein 0.007 0.015 0.0692
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Echinococcus granulosus heat shock protein 0.0062 0.0109 0.0501
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0062 0.0109 0.0109
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.114 0.5691 1
Plasmodium vivax DNA gyrase subunit B, putative 0.1972 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0689 0.3168
Loa Loa (eye worm) heat shock protein 90 0.0062 0.0109 0.0501
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1972 1 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0461 0.2175 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0117 0.0397 0.1824
Trypanosoma cruzi heat shock protein 85, putative 0.0062 0.0109 0.0191
Toxoplasma gondii heat shock protein HSP90 0.0062 0.0109 0.0191
Echinococcus granulosus glycine receptor subunit beta 0.0117 0.0397 0.1824
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0062 0.0109 0.0269
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.114 0.5691 1
Echinococcus multilocularis heat shock protein 0.0062 0.0109 0.0269
Echinococcus multilocularis rho GTPase activating protein 20 0.0141 0.0519 0.1279
Trypanosoma brucei heat shock protein 90, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0069 0.0318
Trypanosoma brucei developmentally regulated phosphoprotein 0.0062 0.0109 0.0191
Leishmania major DNA topoisomerase ii 0.032 0.1445 0.2539
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1972 1 1
Loa Loa (eye worm) hypothetical protein 0.0336 0.1529 0.7031
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0141 0.0519 0.0414
Plasmodium falciparum DNA gyrase subunit B 0.1972 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Brugia malayi Cation transporter family protein 0.0336 0.1529 0.7031
Plasmodium falciparum DNA topoisomerase 2 0.0461 0.2175 0.2089
Loa Loa (eye worm) hypothetical protein 0.032 0.1445 0.6643
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0062 0.0109 0.0501
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0117 0.0397 0.0978
Schistosoma mansoni nAChR subunit 0.0054 0.0069 0.0318
Loa Loa (eye worm) hypothetical protein 0.0336 0.1529 0.7031
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0062 0.0109 0.0269
Entamoeba histolytica hypothetical protein 0.0063 0.0116 0.0035
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0032 0.0078
Brugia malayi kinase, mitochondrial precursor 0.0062 0.0109 0.0501
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Schistosoma mansoni hypothetical protein 0.007 0.015 0.0692
Loa Loa (eye worm) ACC-1 protein 0.0117 0.0397 0.1824
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0054 0.0069 0.017
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0141 0.0519 0.2384
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0125 0.0576
Trypanosoma brucei heat shock protein 90, putative 0.0062 0.0109 0.0191
Trichomonas vaginalis endoplasmin, putative 0.0062 0.0109 0.0501
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0054 0.0069 0.0318
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0062 0.0109 0.033
Brugia malayi DNA topoisomerase III 0.0141 0.0519 0.2384
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0111 0.0111
Onchocerca volvulus 0.0141 0.0519 0.2384
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0054 0.0069 0.0318
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0141 0.0519 0.0911
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0141 0.0519 0.2384
Echinococcus granulosus heat shock protein 90 0.0062 0.0109 0.0501
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0141 0.0519 0.1279
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0116 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Entamoeba histolytica DNA topoisomerase III, putative 0.0141 0.0519 0.1983
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Onchocerca volvulus 0.0054 0.0069 0.0318
Loa Loa (eye worm) hypothetical protein 0.0102 0.0318 0.1462
Mycobacterium tuberculosis Probable two component sensor kinase 0.0062 0.0109 0.0109
Brugia malayi TAR-binding protein 0.0065 0.0125 0.0576
Trypanosoma brucei DNA topoisomerase IA, putative 0.0141 0.0519 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1161 0.5338
Toxoplasma gondii DNA topoisomerase family protein 0.0141 0.0519 0.0911
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0461 0.2175 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0062 0.0109 0.0109
Trypanosoma cruzi DNA topoisomerase II, putative 0.032 0.1445 0.2539
Trypanosoma brucei heat shock protein, putative 0.0062 0.0109 0.0191
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0141 0.0519 0.0911
Brugia malayi Endoplasmin precursor 0.0062 0.0109 0.0501
Giardia lamblia DNA topoisomerase III 0.0141 0.0519 0.2347
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0141 0.0519 0.0911
Echinococcus granulosus glycine receptor subunit alpha 1 0.0117 0.0397 0.1824
Trypanosoma brucei Heat shock protein 83, putative 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Brugia malayi hypothetical protein 0.0054 0.0069 0.0318
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0063 0.0116 0.0534
Schistosoma mansoni nAChR subunit 0.0117 0.0397 0.1824
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.1161 0.5338
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0032 0.0145
Brugia malayi Probable DNA topoisomerase II 0.0461 0.2175 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.023 0.1059
Loa Loa (eye worm) RNA binding protein 0.0065 0.0125 0.0576
Schistosoma mansoni acetylcholine receptor subunit beta 0.0054 0.0069 0.0318
Chlamydia trachomatis DNA gyrase subunit B 0.1293 0.6484 0.6446
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0141 0.0519 0.1569
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1161 0.5338
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0111 0.0195
Loa Loa (eye worm) GABA receptor subunit 0.0063 0.0116 0.0534
Loa Loa (eye worm) hypothetical protein 0.0063 0.0116 0.0534
Onchocerca volvulus 0.0336 0.1529 0.7031
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0062 0.0109 0.0109
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0117 0.0397 0.1824
Entamoeba histolytica DNA topoisomerase III, putative 0.0141 0.0519 0.1983
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0117 0.0397 0.1824
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0069 0.0318
Echinococcus multilocularis glycine receptor subunit beta 0.0117 0.0397 0.0978
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0054 0.0069 0.017
Leishmania major heat shock protein 83-1 0.0062 0.0109 0.0191
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0117 0.0397 0.1824
Plasmodium vivax DNA topoisomerase II, putative 0.0461 0.2175 0.2175
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0109 0.0501
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0336 0.1529 0.7031
Trypanosoma cruzi DNA topoisomerase III, putative 0.0141 0.0519 0.0911
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0054 0.0069 0.017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Mycobacterium tuberculosis Possible two component sensor kinase 0.0062 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0318
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0117 0.0397 0.1824
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824
Brugia malayi DNA topoisomerase III beta-1 0.0141 0.0519 0.2384
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.1824

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.