Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.8611 | 0.8998 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4636 | 0.3822 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.8611 | 0.84 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4636 | 0.3822 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2003 | 0.2003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4636 | 0.3985 |
Onchocerca volvulus | 0.0066 | 0.663 | 0.5 | |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0037 | 0.1319 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4636 | 0.3822 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8611 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0084 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8611 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4636 | 0.3822 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.8611 | 0.8998 |
Brugia malayi | RNA binding protein | 0.0076 | 0.8611 | 0.8611 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4636 | 0.3985 |
Brugia malayi | hypothetical protein | 0.0066 | 0.663 | 0.663 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.7061 | 0.7654 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.5564 | 0.5814 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.8611 | 0.8611 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2003 | 0.2093 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.8611 | 0.8611 |
Echinococcus multilocularis | jun protein | 0.0084 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.5564 | 0.5564 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8611 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4636 | 0.3985 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.957 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8611 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0084 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.7061 | 0.7654 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8611 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.4636 | 0.4845 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.5564 | 0.5814 |
Echinococcus granulosus | jun protein | 0.0084 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.5564 | 0.5564 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.4636 | 0.4636 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.8611 | 0.8998 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.8611 | 0.84 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.