Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Echinococcus multilocularis | mitotic checkpoint serine:threonine protein | 0.0057 | 0.0075 | 0.0076 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1214 | 0.1219 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Echinococcus granulosus | mitotic checkpoint serine:threonine protein | 0.023 | 0.996 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0075 | 0.0621 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0283 | 0.2334 |
Echinococcus multilocularis | mitotic checkpoint serine:threonine protein | 0.023 | 0.996 | 1 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0075 | 0.0621 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1214 | 0.1219 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0283 | 0.2334 |
Brugia malayi | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | 0.0057 | 0.0075 | 0.0621 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1214 | 1 |
Schistosoma mansoni | stomatin-related | 0.0057 | 0.0075 | 0.0621 |
Echinococcus granulosus | mitotic checkpoint serine:threonine protein | 0.0057 | 0.0075 | 0.0076 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1214 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0283 | 0.2334 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1214 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0075 | 0.0621 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Loa Loa (eye worm) | serine/threonine protein kinase | 0.0057 | 0.0075 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0283 | 0.2334 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.