Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0862 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0862 | 0.0862 |
Toxoplasma gondii | beta-tubulin, putative | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0051 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0862 | 0.0862 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0051 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0862 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0862 | 0.0862 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0862 | 0.5 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0051 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0051 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0862 | 0.0862 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0051 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0051 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0051 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0051 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0051 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0051 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0862 | 0.0862 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0862 | 0.0862 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0051 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0862 | 0.5 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0051 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0862 | 0.0862 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0051 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0051 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0051 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0051 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0051 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0051 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0862 | 0.0862 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | beta-tubulin | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0051 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0051 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0051 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0051 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0862 | 0.0862 |
Schistosoma mansoni | tubulin subunit beta | 0.0051 | 1 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0051 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0051 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0862 | 0.0862 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0051 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0862 | 0.0862 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0051 | 1 | 1 |
Leishmania major | beta tubulin | 0.0051 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0862 | 0.0862 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0051 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0862 | 0.0862 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0051 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0862 | 0.0862 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.4368 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.