Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ankyrin 23/unc44 | 0.0054 | 0.0182 | 0.0288 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2322 | 0.3598 |
Schistosoma mansoni | hypothetical protein | 0.0287 | 0.3539 | 0.5593 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0247 | 0.2956 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0274 | 0.0424 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0481 | 0.6327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0182 | 0.0288 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2322 | 0.3598 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2322 | 0.3598 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2322 | 0.3598 |
Onchocerca volvulus | 0.0203 | 0.2322 | 0.3762 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0182 | 0.0282 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0082 | 0.0589 | 0.0415 |
Onchocerca volvulus | Matrilysin homolog | 0.0203 | 0.2322 | 0.3762 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0182 | 0.0282 |
Brugia malayi | Hemopexin family protein | 0.0287 | 0.3539 | 0.5485 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0054 | 0.0182 | 0.0288 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0054 | 0.0182 | 0.0282 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0274 | 0.0424 |
Brugia malayi | Protein kinase domain containing protein | 0.0054 | 0.0182 | 0.0282 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2322 | 0.3598 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1481 | 0.2295 |
Loa Loa (eye worm) | matrixin family protein | 0.049 | 0.6452 | 1 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2322 | 0.3598 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2956 | 0.4582 |
Brugia malayi | Matrixin family protein | 0.049 | 0.6452 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0203 | 0.2322 | 0.3598 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0247 | 0.2956 | 0.5 |
Brugia malayi | Death domain containing protein | 0.0054 | 0.0182 | 0.0282 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.045 | 0.587 | 1 |
Schistosoma mansoni | netrin receptor unc5 | 0.0054 | 0.0182 | 0.0288 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0082 | 0.0589 | 0.0415 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0082 | 0.0589 | 0.0415 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0274 | 0.0424 |
Mycobacterium ulcerans | hydrolase | 0.0247 | 0.2956 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1481 | 0.2295 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0054 | 0.0182 | 0.0282 |
Brugia malayi | Uncoordinated protein 44 | 0.0054 | 0.0182 | 0.0282 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1481 | 0.2295 |
Onchocerca volvulus | Matrilysin homolog | 0.045 | 0.587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2322 | 0.3598 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0247 | 0.2956 | 0.4582 |
Echinococcus granulosus | TNFR CD27 30 40 95 cysteine rich region | 0.0082 | 0.0589 | 0.0415 |
Onchocerca volvulus | 0.0287 | 0.3539 | 0.5902 | |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0737 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.045 | 0.587 | 0.9097 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0274 | 0.0424 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0082 | 0.0589 | 0.0931 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0203 | 0.2322 | 0.3669 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.