Detailed information for compound 1574364

Basic information

Technical information
  • TDR Targets ID: 1574364
  • Name: 1-(4-ethoxyphenyl)-4-(4-pyridin-2-ylpiperazin e-1-carbonyl)pyrrolidin-2-one
  • MW: 394.467 | Formula: C22H26N4O3
  • H donors: 0 H acceptors: 3 LogP: 1.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)N1CC(CC1=O)C(=O)N1CCN(CC1)c1ccccn1
  • InChi: 1S/C22H26N4O3/c1-2-29-19-8-6-18(7-9-19)26-16-17(15-21(26)27)22(28)25-13-11-24(12-14-25)20-5-3-4-10-23-20/h3-10,17H,2,11-16H2,1H3
  • InChiKey: RQBGSINDPVDKQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-ethoxyphenyl)-4-[4-(2-pyridyl)piperazine-1-carbonyl]pyrrolidin-2-one
  • 1-(4-ethoxyphenyl)-4-[oxo-[4-(2-pyridyl)-1-piperazinyl]methyl]-2-pyrrolidinone
  • 1-(4-ethoxyphenyl)-4-[4-(2-pyridyl)piperazine-1-carbonyl]-2-pyrrolidone
  • 1-(4-ethoxyphenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)carbonyl-pyrrolidin-2-one
  • T5435460

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens like-glycosyltransferase Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus Glycosyl transferase family 8 Get druggable targets OG5_130765 All targets in OG5_130765
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni glycosyltransferase-related Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus multilocularis Glycosyltransferase protein LARGE1 Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus multilocularis glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K09668 glycosyltransferase-like protein LARGE, putative Get druggable targets OG5_130765 All targets in OG5_130765
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus Glycosyltransferase protein LARGE1 Get druggable targets OG5_130765 All targets in OG5_130765
Brugia malayi Glycosyl transferase family 8 protein Get druggable targets OG5_130765 All targets in OG5_130765
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) glycosyl transferase family 8 protein Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus multilocularis glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis Glycosyl transferase, family 8 Get druggable targets OG5_130765 All targets in OG5_130765
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis conserved hypothetical protein 0.0064 0.1966 0.5354
Brugia malayi Pre-SET motif family protein 0.003 0.0345 0.0398
Brugia malayi Glycosyl transferase family 8 protein 0.0087 0.3013 0.348
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0084 0.2884 0.8388
Toxoplasma gondii hypothetical protein 0.0033 0.0475 0.0431
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0345 0.0166
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 0.5
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.3372 1
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0084 0.2884 0.8388
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.1849 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 0.5
Schistosoma mansoni glycosyltransferase-related 0.0087 0.3013 0.8814
Brugia malayi Probable ClpP-like protease 0.0094 0.3372 0.3894
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 0.5
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.3372 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.3372 1
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0064 0.1966 0.5354
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0087 0.3013 0.348
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1849 0.5054
Brugia malayi Pre-SET motif family protein 0.0207 0.8659 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.3372 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.3372 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 1
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0084 0.2884 0.8415
Echinococcus granulosus Glycosyl transferase family 8 0.0087 0.3013 0.8834
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1849 0.497
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.1849 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0345 0.0398
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0084 0.2884 0.8388
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0475 0.0431
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.3372 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.3372 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.8659 1
Echinococcus multilocularis Glycosyl transferase, family 8 0.0087 0.3013 0.8814
Loa Loa (eye worm) hypothetical protein 0.0094 0.3372 0.3894
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1849 0.4744
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.3372 1
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0064 0.1966 0.5432
Trichomonas vaginalis set domain proteins, putative 0.0236 1 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 11.8 uM PubChem BioAssay. Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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