Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0878 | 0 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.3899 | 1 | 1 |
Brugia malayi | diacylglycerol acyltransferase | 0.3606 | 0.9029 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0878 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.3606 | 0.9029 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0878 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2728 | 0.6122 | 0.6122 |
Leishmania major | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.3606 | 0.9029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3021 | 0.7093 | 0.7093 |
Leishmania major | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0878 | 0 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0878 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.3606 | 0.9029 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0878 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0878 | 0 | 0.5 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.3899 | 1 | 1 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.3606 | 0.9029 | 0.9029 |
Loa Loa (eye worm) | hypothetical protein | 0.3899 | 1 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.3606 | 0.9029 | 0.9029 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0878 | 0 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0878 | 0 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.3606 | 0.9029 | 0.9029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0878 | 0 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0878 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0878 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0878 | 0 | 0.5 |
Trichomonas vaginalis | porcupine, putative | 0.0878 | 0 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.3606 | 0.9029 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0878 | 0 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0878 | 0 | 0.5 |
Onchocerca volvulus | 0.0878 | 0 | 0.5 | |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.3606 | 0.9029 | 0.9029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to wild type recombinant GST-PDK1 expressed in HEK293 cells assessed as 50% enzyme activation relative to basal activity | ChEMBL. | 19606904 | |
FC (binding) | Binding affinity to wild type recombinant GST-PDK1 expressed in HEK293 cells assessed as maximum enzyme activation | ChEMBL. | 19606904 | |
Kd (binding) | Binding affinity to PDK1 (50 to 359) by isothermal titration calorimetry | ChEMBL. | 19606904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.