Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0283 | 0.3577 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Echinococcus multilocularis | geminin | 0.0203 | 0.2422 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0303 | 0.1207 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0045 | 0.0165 | 0.0636 |
Schistosoma mansoni | loxhd1 | 0.0045 | 0.0165 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Echinococcus multilocularis | Protein lozenge | 0.0049 | 0.0222 | 0.08 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0063 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | doublecortin family protein | 0.0045 | 0.0165 | 0.0165 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2422 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0063 | 0.0416 | 0.1678 |
Loa Loa (eye worm) | runx1 | 0.0049 | 0.0222 | 0.0222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0303 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0045 | 0.0165 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0303 | 0.1207 |
Echinococcus granulosus | lamin | 0.0063 | 0.0416 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0416 | 0.0416 |
Schistosoma mansoni | lamin | 0.0063 | 0.0416 | 0.1613 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0303 | 0.1138 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0045 | 0.0165 | 0.0636 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0045 | 0.0165 | 0.0563 |
Schistosoma mansoni | intermediate filament proteins | 0.0063 | 0.0416 | 0.1613 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0031 | 0.0031 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0303 | 0.1138 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0063 | 0.0416 | 0.0416 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0045 | 0.0165 | 0.0636 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0198 | 0.2355 | 0.9721 |
Echinococcus multilocularis | lamin | 0.0063 | 0.0416 | 0.1613 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2422 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.0045 | 0.0165 | 0.0563 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.0393 | 0.1513 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0165 | 0.0563 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0398 | 0.5214 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0249 | 0.3084 | 0.3084 |
Brugia malayi | Doublecortin family protein | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0031 | 0.0078 |
Echinococcus multilocularis | RUN | 0.0045 | 0.0165 | 0.0563 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0198 | 0.2355 | 0.9724 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0249 | 0.3084 | 0.3084 |
Brugia malayi | intermediate filament protein | 0.0063 | 0.0416 | 0.0416 |
Schistosoma mansoni | lipoxygenase | 0.0198 | 0.2355 | 0.9721 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0303 | 0.0303 |
Giardia lamblia | DNA repair protein RAD52 | 0.0398 | 0.5214 | 0.5 |
Schistosoma mansoni | lozenge | 0.0049 | 0.0222 | 0.08 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0303 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0165 | 0.0563 |
Onchocerca volvulus | 0.0063 | 0.0416 | 0.1087 | |
Echinococcus granulosus | RUN | 0.0045 | 0.0165 | 0.0636 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0165 | 0.0563 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0732 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0063 | 0.0416 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.04 | 0.04 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0303 | 0.1138 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0031 | 0.0031 |
Echinococcus multilocularis | lamin dm0 | 0.0063 | 0.0416 | 0.1613 |
Onchocerca volvulus | 0.0045 | 0.0165 | 0.0379 | |
Echinococcus granulosus | geminin | 0.0203 | 0.2422 | 1 |
Echinococcus multilocularis | musashi | 0.0063 | 0.0416 | 0.1613 |
Onchocerca volvulus | 0.0063 | 0.0416 | 0.1087 | |
Schistosoma mansoni | lamin | 0.0063 | 0.0416 | 0.1613 |
Trichomonas vaginalis | set domain proteins, putative | 0.0283 | 0.3577 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.1193 | 0.486 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0045 | 0.0165 | 0.0563 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0045 | 0.0165 | 0.0563 |
Loa Loa (eye worm) | intermediate filament protein | 0.0063 | 0.0416 | 0.0416 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0031 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0045 | 0.0165 | 0.5 |
Onchocerca volvulus | 0.0045 | 0.0165 | 0.0379 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of rabbit reticulocytes arachidonate 15-lipoxygenase | ChEMBL. | 21937153 | |
Inhibition (functional) | = 90 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/mL by microplate alamar blue assay | ChEMBL. | 21937153 |
MIC (functional) | = 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | ChEMBL. | 21937153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.