Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-akt murine thymoma viral oncogene homolog 1 | Starlite/ChEMBL | References |
Homo sapiens | v-akt murine thymoma viral oncogene homolog 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0058 | 0.447 | 0.0219 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0061 | 0.4899 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0088 | 0.9571 | 0.1512 |
Trichomonas vaginalis | dolichyl-diphosphooligosaccharide--protein glycosyltransferase, putative | 0.0087 | 0.9495 | 0.9495 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0061 | 0.4899 | 0.1054 |
Entamoeba histolytica | dolichyl-diphosphooligosaccharide-protein glycotransferase, putative | 0.0087 | 0.9495 | 0.942 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0061 | 0.4899 | 0.4141 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0061 | 0.4899 | 0.4141 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0061 | 0.4899 | 0.1054 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Echinococcus granulosus | dolichyl diphosphooligosaccharide protein | 0.0087 | 0.9495 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0088 | 0.9571 | 0.9507 |
Entamoeba histolytica | dolichyl-di-phosphooligosaccharide-protein glycotransferase, putative | 0.0087 | 0.9495 | 0.942 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.009 | 1 | 1 |
Echinococcus multilocularis | dolichyl diphosphooligosaccharide protein | 0.0087 | 0.9495 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.009 | 1 | 0.5 |
Plasmodium vivax | dolichyl-diphosphooligosaccharide--protein glycosyltransferase, putative | 0.0087 | 0.9495 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0058 | 0.447 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0058 | 0.447 | 0.0219 |
Trypanosoma cruzi | Protein kinase B | 0.0061 | 0.4899 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Plasmodium falciparum | dolichyl-diphosphooligosaccharide--protein glycosyltransferase, putative | 0.0087 | 0.9495 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0058 | 0.447 | 0.0219 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0088 | 0.9571 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0088 | 0.9571 | 0.1512 |
Entamoeba histolytica | protein kinase 2, putative | 0.0058 | 0.447 | 0.3648 |
Trichomonas vaginalis | AGC family protein kinase | 0.009 | 1 | 1 |
Schistosoma mansoni | dolichyl-diphosphooligosaccharide-protein glycosyltransferase | 0.0087 | 0.9495 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA | ChEMBL. | 20151677 | |
IC50 (functional) | = 3.8 nM | Inhibition of PKB in human PC3M cells assessed as GSK3-beta phosphorylation by ELISA | ChEMBL. | 20151677 |
IC50 (binding) | = 4.9 nM | Inhibition of PKBbeta by radiometric filter binding assay | ChEMBL. | 20151677 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.