Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase alpha | Starlite/ChEMBL | References |
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0147 | 0.2134 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0077 | 0.0588 | 0.1228 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0196 | 0.3222 | 0.3086 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0077 | 0.0588 | 0.5 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0203 | 0.338 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0203 | 0.338 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0203 | 0.338 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0203 | 0.338 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0147 | 0.2134 | 0.5 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.05 | 0.9996 | 1 |
Onchocerca volvulus | 0.006 | 0.0198 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.862 | 0.8595 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0077 | 0.0588 | 0.1741 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0077 | 0.0588 | 0.1228 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0203 | 0.338 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0077 | 0.0588 | 0.5 |
Chlamydia trachomatis | biotin carboxylase | 0.007 | 0.043 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0077 | 0.0588 | 0.5 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0077 | 0.0588 | 0.5 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0077 | 0.0588 | 0.1228 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0203 | 0.338 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0126 | 0.1662 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0077 | 0.0588 | 0.1741 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0203 | 0.338 | 1 |
Onchocerca volvulus | 0.006 | 0.0198 | 0.5 | |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0077 | 0.0588 | 0.1228 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0077 | 0.0588 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0077 | 0.0588 | 0.5 |
Schistosoma mansoni | pyruvate carboxylase | 0.0077 | 0.0588 | 0.1228 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0196 | 0.3222 | 0.3085 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0077 | 0.0588 | 0.5 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0077 | 0.0588 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.