Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC DYRK | 0.0266 | 0.688 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0341 | 0.9888 | 0.9888 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0266 | 0.688 | 0.5 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0266 | 0.688 | 1 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.688 | 0.6923 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0266 | 0.688 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0341 | 0.9888 | 0.9888 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0266 | 0.688 | 0.6923 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Brugia malayi | hypothetical protein | 0.0341 | 0.9888 | 1 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.688 | 0.6923 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.688 | 0.6923 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0266 | 0.688 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0097 | 0.0112 | 0.0112 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0266 | 0.688 | 1 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.688 | 0.6923 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0266 | 0.688 | 0.6923 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.9888 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.688 | 0.6923 |
Brugia malayi | GSG2 | 0.0341 | 0.9888 | 1 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.688 | 0.6923 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0266 | 0.688 | 0.688 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0266 | 0.688 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR alpha; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR gamma; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR beta; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR alpha; Not active | ChEMBL. | No reference |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR beta; Not active | ChEMBL. | No reference |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR gamma; Not active | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-alpha transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-beta transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum RAR-gamma transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-alpha transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-beta transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum RAR-gamma transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.