Detailed view for LOAG_12011

Basic information

TDR Targets ID: 941311
Loa Loa (eye worm), haspin protein kinase
Source Database / ID:  KEGG  

pI: 6.8273 | Length (AA): 447 | MW (Da): 52081 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12330   Haspin like kinase domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
96 436 2wb8 (A) 453 798 23.00 0.000000000028 1 1.06936 -0.15
126 433 6g38 (A) 483 794 29.00 0 1 1.04684 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130553)

Species Accession Gene Product
Arabidopsis thaliana AT1G09450   protein kinase HASPIN
Brugia malayi Bm1_53130   GSG2
Brugia malayi Bm1_12320   hypothetical protein
Caenorhabditis elegans CELE_Y18H1A.10   Protein Y18H1A.10
Caenorhabditis elegans CELE_F22H10.5   Protein F22H10.5
Caenorhabditis elegans CELE_Y40A1A.1   Protein Y40A1A.1
Caenorhabditis elegans CELE_C01H6.9   Protein C01H6.9
Drosophila melanogaster Dmel_CG40080   CG40080 gene product from transcript CG40080-RA
Echinococcus granulosus EgrG_001165000   serine:threonine protein kinase haspin
Echinococcus granulosus EgrG_000667600   serine:threonine protein kinase haspin
Echinococcus granulosus EgrG_000667650   serine:threonine protein kinase haspin
Echinococcus multilocularis EmuJ_000667600   serine:threonine protein kinase haspin
Echinococcus multilocularis EmuJ_001165000   serine:threonine protein kinase haspin
Homo sapiens ENSG00000177602   germ cell associated 2 (haspin)
Loa Loa (eye worm) LOAG_03451   haspin protein kinase
Loa Loa (eye worm) LOAG_12357   haspin protein kinase
Loa Loa (eye worm) LOAG_12011   haspin protein kinase
Mus musculus ENSMUSG00000050107   germ cell-specific gene 2
Oryza sativa 4344041   Os07g0637500
Saccharomyces cerevisiae YBL009W   Alk2p
Schistosoma japonicum Sjp_0209470   ko:K08286 protein-serine/threonine kinase [EC2.7.11.-], putative
Schistosoma japonicum Sjp_0022980   Serine/threonine-protein kinase haspin, putative
Schistosoma mansoni Smp_158950   hypothetical protein
Schmidtea mediterranea mk4.006908.02   Serine/threonine-protein kinase haspin
Schmidtea mediterranea mk4.007448.00   Serine/threonine-protein kinase haspin

Essentiality

LOAG_12011 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y18H1A.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y18H1A.10 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens germ cell associated 2 (haspin) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.049 0.991 0.991
0.05 0.674 0.9894
0.1051 0.9642 0.9642
0.0351 0.9887 0.9885
0.0495 0.9884 0.9884
0.0806 0.7362 0.7361
0.0082 0.9918 0.9918
0.0341 0.9888 0.9888
0.0509 0.5756 0.5756
0.0806 0.7362 0.7361
0.0489 0.991 0.991
0.0644 0.9921 0.9921
0.0576 0.9906 0.9906
0.0756 0.3489 0.2786
0.0495 0.9917 0.9914
0.02 0.6254 0.6188
0.0722 0.7001 0.9919
0.0066 0.3945 0.3945
0.0503 0.8599 0.9248
0.0573 0.5801 0.9923
0.0572 0.6324 0.6568
0.0339 0.316 0.9905
0.0203 0.4512 0.4512
0.0276 0.2994 0.2986
0.0347 0.5523 0.729
0.0337 0.9754 0.99
0.0139 0.9918 0.9918
0.0648 0.7414 0.9775
0.1051 0.9642 0.9642
0.0272 0.2626 0.9909
0.0067 0.336 0.336
0.0414 0.9896 0.9896
0.0072 0.8949 0.8949
0.0271 0.3601 0.8228
0.0135 0.9878 0.9878
0.0494 0.4148 0.9898
0.0577 0.9919 0.9914
0.0079 0.9918 0.9918
0.05 0.674 0.9894
0.0493 0.4121 0.992
0.0342 0.5423 0.9911
0.0646 0.5443 0.992
0.0203 0.2634 0.9856
0.0203 0.5357 0.5302
0.0728 0.3292 0.9885
0.0134 0.9918 0.9918
0.0337 0.9886 0.9886
0.0582 0.6501 0.9745
0.0817 0.9921 0.9921
0.0481 0.9918 0.9918
0.0794 0.8081 0.992
0.0066 0.3213 0.3213
0.027 0.9876 0.9876
0.0271 0.3601 0.8228
0.05 0.3149 0.9912
0.0568 0.6654 0.9912
0.0575 0.9914 0.9914
0.048 0.5267 0.9918
0.05 0.986 0.9857
0.0416 0.4507 0.449
0.0649 0.8889 0.9931
0.0136 0.9875 0.9875
0.0202 0.9918 0.9918
0.0559 0.3798 0.3797
0.0756 0.3489 0.2786
0.0489 0.991 0.991
0.041 0.992 0.992
0.0271 0.2735 0.9914
0.0581 0.9915 0.9915
0.0817 0.9921 0.9921
0.0064 0.3785 0.3785
0.0725 0.9926 0.9926
0.0337 0.6374 0.6374
0.05 0.986 0.9857
0.0136 0.4033 0.4646
0.0568 0.6654 0.9912
0.0351 0.5664 0.9917
0.0339 0.9886 0.9885
0.0351 0.5664 0.9917
0.0488 0.991 0.991
0.0067 0.6427 0.6427
0.0133 0.4756 0.9925
0.0082 0.6456 0.6456
0.0575 0.4643 0.9914
0.0276 0.2994 0.2986
0.0504 0.5604 0.991
0.0068 0.9918 0.9918
0.0136 0.5042 0.5042
0.0137 0.6726 0.6726
0.0414 0.9896 0.9896
0.0337 0.9754 0.99
0.0344 0.9888 0.9888
0.035 0.3295 0.9924
0.0072 0.8949 0.8949
0.0652 0.6886 0.7528
0.0796 0.8323 0.9917
0.0079 0.9918 0.9918
0.058 0.6776 0.6776
0.0274 0.8631 0.9876
0.05 0.674 0.9894
0.0571 0.6392 0.9765
0.0135 0.6587 0.9918
0.0638 0.9915 0.9915
0.0348 0.5425 0.9316
0.0341 0.9914 0.9914
0.0581 0.5853 0.9914
0.0981 0.992 0.992
0.0791 0.9921 0.9921
0.0497 0.3892 0.9912
0.0072 0.8949 0.8949
0.0136 0.3567 0.3508
0.0334 0.988 0.988
0.0638 0.9915 0.9915
0.0495 0.5307 0.5306
0.0873 0.9926 0.9926
0.0344 0.9918 0.9918
0.0955 0.9827 0.9827
0.08 0.992 0.992
0.0483 0.9907 0.9907
0.0416 0.4507 0.449
0.0794 0.8081 0.992
0.1051 0.9642 0.9642
0.0136 0.3567 0.3508
0.0206 0.6274 0.9888
0.00892737 0.522996 0.522996
0.0645 0.738 0.738
0.0209 0.7055 0.8127
0.1051 0.9642 0.9642
0.0638 0.4737 0.4736
0.0728 0.3292 0.9885
0.0501 0.9911 0.9911
0.0495 0.9884 0.9884
0.0495 0.991 0.991
0.034 0.9914 0.9914
0.0802 0.9925 0.9922
0.06 0.9918 0.9918
0.0559 0.3798 0.3797
0.0079 0.9918 0.9918
0.0791 0.992 0.992
0.0354 0.9902 0.9901
0.0341 0.9886 0.9886
0.0582 0.9903 0.9904
0.027 0.6895 0.989
0.0066 0.9918 0.9918
0.0495 0.9884 0.9884
0.0495 0.5307 0.5306
0.02 0.9919 0.9918
0.0638 0.4737 0.4736
0.0353 0.3618 0.9902

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_12011 (Loa Loa (eye worm)), haspin protein kinase
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