Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0769 | 0.0135 | 0.027 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0769 | 0.0135 | 0.027 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0769 | 0.0135 | 0.0135 |
Schistosoma mansoni | choline o-acyltransferase | 0.0689 | 0 | 0.5 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3647 | 0.5003 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3647 | 0.5003 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0769 | 0.0135 | 0.027 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3647 | 0.5003 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0769 | 0.0135 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.6601 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3647 | 0.5003 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0769 | 0.0135 | 1 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3647 | 0.5003 | 1 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0689 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0769 | 0.0135 | 0.0135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to MAO-B in human brain hippocampus at 4 MBq after 90 mins by autoradiography | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain cortical gray matter at 4 MBq after 90 mins by autoradiography in presence of 10 uM MAO-B inhibitor L-deprenyl | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain cortical gray matter at 4 MBq after 90 mins by autoradiography in presence of 10 uM MAO-B inhibitor rasagiline | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain cortical gray matter at 4 MBq after 90 mins by autoradiography in presence of 10 uM MAO-A inhibitor pirlindole | ChEMBL. | 21923198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.