Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.3224 | 0.222 | 0.5024 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.5045 | 0.442 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.5045 | 0.442 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.5045 | 0.442 | 1 |
Onchocerca volvulus | 0.1386 | 0 | 0.5 | |
Onchocerca volvulus | 0.1386 | 0 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.3224 | 0.222 | 0.5024 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.3224 | 0.222 | 0.5024 |
Schistosoma mansoni | choline o-acyltransferase | 0.1386 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.3224 | 0.222 | 0.222 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.3224 | 0.222 | 0.222 |
Schistosoma mansoni | choline o-acyltransferase | 0.1386 | 0 | 0.5 |
Onchocerca volvulus | 0.1386 | 0 | 0.5 | |
Onchocerca volvulus | 0.1386 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.5045 | 0.442 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.3224 | 0.222 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.5045 | 0.442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.9664 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.3224 | 0.222 | 0.5024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 121 uL/min/10^6cells | Intrinsic clearance in human hepatocytes assessed per million cells | ChEMBL. | 21870878 |
Ki (functional) | = 0.73 nM | Antagonist activity at human recombinant M3 receptor expressed in CHO-K1 cells assessed as inhibition of carbamoyl choline-induced calcium currents after 4 hrs by fluorimetry | ChEMBL. | 21870878 |
T1/2 (binding) | > 1440 min | Displacement of [3H]-NMS from human recombinant M3 receptor expressed in CHO cells assessed as dissociation half life at 100 fold human M1 receptor binding Ki concentration after 2 hrs by dilution-offset filter binding assay | ChEMBL. | 21870878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.