Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1178 | 0.4144 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1178 | 0.4144 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1178 | 0.4144 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1178 | 0.4144 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1178 | 0.4144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2056 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0557 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 178 nM | Inhibition of recombinant JNK1 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay | ChEMBL. | 21813278 |
IC50 (binding) | = 280 nM | Inhibition of recombinant JNK3 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay | ChEMBL. | 21813278 |
IC50 (binding) | = 337 nM | Inhibition of recombinant JNK2 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay | ChEMBL. | 21813278 |
Stability (ADMET) | = 3 % | Oxidative metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins | ChEMBL. | 21813278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.