Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.5279 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1108 | 0.1233 | 0.2328 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2714 | 0.461 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.062 | 0.0209 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.062 | 0.0209 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2714 | 0.461 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0635 | 0.0239 | 0.0031 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1108 | 0.1233 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1108 | 0.1233 | 0.1047 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.0239 | 0.0031 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0635 | 0.0239 | 0.0031 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1108 | 0.1233 | 0.2328 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1108 | 0.1233 | 0.2328 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1108 | 0.1233 | 0.2328 |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.0239 | 0.0031 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2714 | 0.461 | 1 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1108 | 0.1233 | 0.1047 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2714 | 0.461 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2714 | 0.461 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of BACE1 in human HEK293 cells overexpressing APP with Swedish mutation assessed as inhibition of amyloid beta 40 production | ChEMBL. | 19375914 | |
IC50 (binding) | = 242 nM | Binding affinity to BACE assessed as displacement of [3H]BMS-599240 | ChEMBL. | 19375914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.