Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Schistosoma japonicum | ko:K00799 glutathione S-transferase [EC2.5.1.18], putative | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Schistosoma japonicum | ko:K00799 glutathione S-transferase [EC2.5.1.18], putative | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline o-acyltransferase | 0.0723 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1278 | 0.1142 | 0.1142 |
Onchocerca volvulus | 0.0723 | 0 | 0.5 | |
Onchocerca volvulus | 0.0723 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3184 | 0.507 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1278 | 0.1142 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3184 | 0.507 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1278 | 0.1142 | 0.2253 |
Loa Loa (eye worm) | hypothetical protein | 0.5578 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1278 | 0.1142 | 0.2253 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3184 | 0.507 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3184 | 0.507 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3184 | 0.507 | 1 |
Onchocerca volvulus | 0.0723 | 0 | 0.5 | |
Onchocerca volvulus | 0.0723 | 0 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1278 | 0.1142 | 0.2253 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1278 | 0.1142 | 0.2253 |
Schistosoma mansoni | choline o-acyltransferase | 0.0723 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1278 | 0.1142 | 0.1142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 nM | Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assay | ChEMBL. | 21466167 |
IC50 (binding) | = 0.001 uM | Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cells | ChEMBL. | 19748780 |
IC50 (functional) | = 0.2 uM | Inhibition of PGE2 production in LPS-stimulated human whole blood | ChEMBL. | 19748780 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19748780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.