Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1538 | 0.5176 | 1 |
Onchocerca volvulus | 0.0324 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0493 | 0.0719 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0493 | 0.0719 | 0.0719 |
Schistosoma mansoni | choline o-acyltransferase | 0.0324 | 0 | 0.5 |
Onchocerca volvulus | 0.0324 | 0 | 0.5 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0493 | 0.0719 | 0.1389 |
Loa Loa (eye worm) | hypothetical protein | 0.2669 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1538 | 0.5176 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1538 | 0.5176 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0493 | 0.0719 | 0.1389 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1538 | 0.5176 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1538 | 0.5176 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0324 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0493 | 0.0719 | 0.0719 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0493 | 0.0719 | 0.1389 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0493 | 0.0719 | 0.1389 |
Onchocerca volvulus | 0.0324 | 0 | 0.5 | |
Onchocerca volvulus | 0.0324 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.