Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2144 | 0.5024 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2144 | 0.5024 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0492 | 0.0229 | 0.0457 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2144 | 0.5024 | 1 |
Onchocerca volvulus | 0.0413 | 0 | 0.5 | |
Onchocerca volvulus | 0.0413 | 0 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0492 | 0.0229 | 0.0457 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0492 | 0.0229 | 0.0457 |
Schistosoma mansoni | choline o-acyltransferase | 0.0413 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0492 | 0.0229 | 0.0229 |
Onchocerca volvulus | 0.0413 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0413 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0492 | 0.0229 | 0.0229 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0492 | 0.0229 | 1 |
Onchocerca volvulus | 0.0413 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2144 | 0.5024 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2144 | 0.5024 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0492 | 0.0229 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.3859 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.