Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1585 | 0.1318 | 0.2922 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1585 | 0.1318 | 0.2922 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3435 | 0.4512 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3435 | 0.4512 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1585 | 0.1318 | 0.2922 |
Schistosoma mansoni | choline o-acyltransferase | 0.0822 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3435 | 0.4512 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3435 | 0.4512 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1585 | 0.1318 | 0.1318 |
Loa Loa (eye worm) | hypothetical protein | 0.6612 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1585 | 0.1318 | 0.2922 |
Onchocerca volvulus | 0.0822 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3435 | 0.4512 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1585 | 0.1318 | 1 |
Onchocerca volvulus | 0.0822 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0822 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1585 | 0.1318 | 0.1318 |
Onchocerca volvulus | 0.0822 | 0 | 0.5 | |
Onchocerca volvulus | 0.0822 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.