Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SET domain-containing protein | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1978 | 0.1868 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0144 | 0.274 | 0.274 |
Schistosoma mansoni | enhancer of zeste ezh | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.196 | 0.1849 |
Brugia malayi | Pre-SET motif family protein | 0.0038 | 0.0553 | 0.0553 |
Trichomonas vaginalis | set domain proteins, putative | 0.0038 | 0.0553 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0038 | 0.0553 | 0.0459 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0359 | 0.0359 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0019 | 0.0178 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Onchocerca volvulus | 0.0144 | 0.274 | 1 | |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0393 | 0.0393 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.1064 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0038 | 0.0553 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0019 | 0.0178 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.0497 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.0359 | 0.1312 | |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0393 | 0.0296 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0099 | 0.0099 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.0497 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0038 | 0.0553 | 0.0553 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0013 | 0.0038 | 0.0038 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.036 | 0.0263 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0038 | 0.0553 | 0.0459 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0038 | 0.0553 | 0.0553 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0359 | 0.0359 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.0081 | 0.131 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0069 | 0.1197 | 0.1197 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0359 | 0.0227 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0038 | 0.0553 | 0.0553 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0038 | 0.0553 | 0.0459 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0135 | 0.0036 |
Brugia malayi | SET domain containing protein | 0.0116 | 0.2153 | 0.2153 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0393 | 0.0296 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0393 | 0.0393 |
Onchocerca volvulus | 0.0038 | 0.0553 | 0.202 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0135 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0553 | 0.0424 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0017 | 0.0133 | 0.0133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.