Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | serine/threonine protein kinase 6 | 0.0251 | 0.2353 | 0.2328 |
Brugia malayi | hypothetical protein | 0.0073 | 0.064 | 0.0609 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0251 | 0.2353 | 0.7783 |
Trichomonas vaginalis | AGC family protein kinase | 0.0251 | 0.2353 | 0.7217 |
Echinococcus multilocularis | neuroglian | 0.0013 | 0.0058 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0003 |
Trichomonas vaginalis | AGC family protein kinase | 0.0251 | 0.2353 | 0.7217 |
Echinococcus multilocularis | aurora kinase A | 0.0251 | 0.2353 | 0.7783 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1906 | 0.6284 |
Onchocerca volvulus | 0.0154 | 0.1417 | 0.3275 | |
Brugia malayi | Protein kinase domain containing protein | 0.0319 | 0.3013 | 0.299 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0251 | 0.2353 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0319 | 0.3013 | 1 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0319 | 0.3013 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0091 | 0.0195 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0251 | 0.2353 | 0.7783 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0251 | 0.2353 | 0.7808 |
Loa Loa (eye worm) | AUR protein kinase | 0.0251 | 0.2353 | 0.233 |
Echinococcus granulosus | neuroglian | 0.0013 | 0.0058 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0003 |
Leishmania major | protein kinase, putative | 0.0251 | 0.2353 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0319 | 0.3013 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0169 | 0.1559 | 0.1531 |
Brugia malayi | serine/threonine kinase 12 | 0.0251 | 0.2353 | 0.2328 |
Schistosoma mansoni | protein kinase | 0.0251 | 0.2353 | 0.7808 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0251 | 0.2353 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0251 | 0.2353 | 0.7217 |
Loa Loa (eye worm) | TTK protein kinase | 0.0319 | 0.3013 | 0.2992 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0033 | 0.0109 |
Toxoplasma gondii | aurora kinase | 0.0251 | 0.2353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.064 | 0.0612 |
Echinococcus granulosus | aurora kinase A | 0.0251 | 0.2353 | 0.7783 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0251 | 0.2353 | 0.2328 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0003 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0033 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0091 | 0.0061 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.0065 | 0.0109 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0251 | 0.2353 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0319 | 0.3013 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0003 |
Entamoeba histolytica | protein kinase , putative | 0.0251 | 0.2353 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0158 | 0.1452 | 0.3421 |
Loa Loa (eye worm) | AUR protein kinase | 0.0251 | 0.2353 | 0.233 |
Trichomonas vaginalis | AGC family protein kinase | 0.0251 | 0.2353 | 0.7217 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1906 | 0.6325 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0003 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0169 | 0.1559 | 0.1533 |
Schistosoma mansoni | cell adhesion molecule | 0.0014 | 0.0065 | 0.0217 |
Trypanosoma brucei | aurora B kinase | 0.0251 | 0.2353 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0251 | 0.2353 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0251 | 0.2353 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.1906 | 0.6284 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0319 | 0.3013 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0251 | 0.2353 | 0.5 |
Echinococcus granulosus | twitchin | 0.0017 | 0.0098 | 0.0217 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0319 | 0.3013 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0251 | 0.2353 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0091 | 0.0195 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0251 | 0.2353 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0319 | 0.3013 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0251 | 0.2353 | 0.233 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0065 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1906 | 0.6325 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0091 | 0.0061 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0251 | 0.2353 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0033 | 0.0109 |
Schistosoma mansoni | nephrin | 0.0013 | 0.0058 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.