Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0457 | 0.4433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0203 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0203 | 0.0458 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0358 | 0.338 | 0.7624 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0358 | 0.338 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0147 | 0.1128 | 0.2545 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0203 | 0.0458 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0147 | 0.1128 | 0.2545 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0203 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.338 | 0.7624 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0457 | 0.4433 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0457 | 0.4433 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0457 | 0.4433 | 0.3725 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0147 | 0.1128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1513 | 0.3413 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1128 | 0.2545 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0457 | 0.4433 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0358 | 0.338 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0457 | 0.4433 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0147 | 0.1128 | 0.2545 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0358 | 0.338 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0147 | 0.1128 | 0.2545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.