Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0061 | 0.0132 |
Brugia malayi | Fibronectin type III domain containing protein | 0.001 | 0.0061 | 0.0061 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0166 | 0.2377 | 0.2377 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0149 | 0.0323 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0184 | 0.2658 | 0.5757 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0061 | 0.0132 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0061 | 0.0132 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0316 | 0.4616 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0184 | 0.2658 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.011 | 0.0239 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0184 | 0.2658 | 1 |
Echinococcus granulosus | neuroglian | 0.0013 | 0.01 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0184 | 0.2658 | 0.5 |
Onchocerca volvulus | 0.0151 | 0.2162 | 0.4683 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0316 | 0.4616 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0184 | 0.2658 | 0.5757 |
Echinococcus granulosus | defective proboscis extension response | 0.001 | 0.0061 | 0.0132 |
Echinococcus granulosus | twitchin | 0.0016 | 0.0152 | 0.0329 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0316 | 0.4616 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.2658 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0184 | 0.2658 | 0.5 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0618 | 0.0618 |
Schistosoma mansoni | nephrin | 0.0013 | 0.01 | 0.0216 |
Loa Loa (eye worm) | AUR protein kinase | 0.0184 | 0.2658 | 0.2658 |
Leishmania major | protein kinase, putative | 0.0184 | 0.2658 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.0184 | 0.2658 | 0.5757 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0155 | 0.2214 | 0.4797 |
Entamoeba histolytica | protein kinase , putative | 0.0184 | 0.2658 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Brugia malayi | Protein kinase domain containing protein | 0.0316 | 0.4616 | 0.4616 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0618 | 0.0618 |
Echinococcus multilocularis | neuroglian | 0.0013 | 0.01 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Trichomonas vaginalis | AGC family protein kinase | 0.0184 | 0.2658 | 0.5102 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.001 | 0.0061 | 0.0061 |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0011 | 0.0024 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.001 | 0.0061 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.011 | 0.011 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0184 | 0.2658 | 0.5757 |
Loa Loa (eye worm) | AUR protein kinase | 0.0184 | 0.2658 | 0.2658 |
Brugia malayi | serine/threonine kinase 12 | 0.0184 | 0.2658 | 0.2658 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0009 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0149 | 0.0149 |
Echinococcus granulosus | Immunoglobulin | 0.001 | 0.0061 | 0.0132 |
Trichomonas vaginalis | AGC family protein kinase | 0.0184 | 0.2658 | 0.5102 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0316 | 0.4616 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0184 | 0.2658 | 0.5102 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0184 | 0.2658 | 0.2658 |
Schistosoma mansoni | protein kinase | 0.0184 | 0.2658 | 0.5757 |
Loa Loa (eye worm) | TTK protein kinase | 0.0316 | 0.4616 | 0.4616 |
Onchocerca volvulus | 0.0048 | 0.0618 | 0.1338 | |
Brugia malayi | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0061 | 0.0132 |
Trypanosoma brucei | aurora B kinase | 0.0184 | 0.2658 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0184 | 0.2658 | 0.2658 |
Echinococcus multilocularis | aurora kinase A | 0.0184 | 0.2658 | 0.5757 |
Toxoplasma gondii | aurora kinase | 0.0184 | 0.2658 | 1 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0316 | 0.4616 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0014 | 0.011 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0316 | 0.4616 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0184 | 0.2658 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0316 | 0.4616 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0149 | 0.0323 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0166 | 0.2377 | 0.2377 |
Trichomonas vaginalis | AGC family protein kinase | 0.0184 | 0.2658 | 0.5102 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0184 | 0.2658 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.2658 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0184 | 0.2658 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0061 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0061 | 0.0061 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0184 | 0.2658 | 0.2658 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0149 | 0.0149 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.