Detailed information for compound 158801

Basic information

Technical information
  • TDR Targets ID: 158801
  • Name: 4-[4-[2-(4-aminophenyl)ethyl]piperazin-1-yl]a niline
  • MW: 296.41 | Formula: C18H24N4
  • H donors: 2 H acceptors: 0 LogP: 2.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)CCN1CCN(CC1)c1ccc(cc1)N
  • InChi: 1S/C18H24N4/c19-16-3-1-15(2-4-16)9-10-21-11-13-22(14-12-21)18-7-5-17(20)6-8-18/h1-8H,9-14,19-20H2
  • InChiKey: VIEIHNHNUXFOJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-[2-(4-aminophenyl)ethyl]-1-piperazinyl]aniline
  • [4-[4-[2-(4-aminophenyl)ethyl]piperazino]phenyl]amine
  • [4-[4-[2-(4-aminophenyl)ethyl]piperazin-1-yl]phenyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0029 0.0444 0.2055
Brugia malayi Major Facilitator Superfamily protein 0.0013 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Onchocerca volvulus 0.0013 0.0042 0.0123
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Plasmodium vivax lysine--tRNA ligase, putative 0.0021 0.0243 0.0201
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0033 0.055 0.0779
Plasmodium falciparum calcium-dependent protein kinase 3 0.0029 0.0445 0.0404
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Schistosoma mansoni sugar transporter 0.0013 0.0042 0.0159
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0152 0.3622 0.5495
Onchocerca volvulus 0.0013 0.0042 0.0123
Schistosoma mansoni sugar transporter 0.0013 0.0042 0.0159
Loa Loa (eye worm) sugar transporter 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0048 0.0944 0.3426
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0009 0.0031
Leishmania major glucose transporter, lmgt2 0.0029 0.0454 0.8107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0021 0.0243 0.395
Echinococcus granulosus calcium dependent protein kinase 0.0027 0.0398 0.1839
Echinococcus multilocularis lysyl tRNA synthetase 0.0021 0.0243 0.1105
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0033 0.055 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0551 0.1999
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Echinococcus multilocularis solute carrier family 22 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Leishmania major protein kinase, putative 0.0029 0.0444 0.7919
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0152 0.3622 0.3595
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Echinococcus multilocularis General substrate transporter 0.0081 0.1787 0.839
Loa Loa (eye worm) hypothetical protein 0.0119 0.2756 1
Onchocerca volvulus 0.0013 0.0042 0.0123
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0094 0.2128 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0095 0.0405
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Echinococcus granulosus solute carrier family 22 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0021 0.0243 0.0881
Echinococcus granulosus GPCR family 2 0.0015 0.0095 0.0405
Leishmania major lysyl-tRNA synthetase, putative 0.0021 0.0243 0.395
Echinococcus granulosus solute carrier family 22 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Schistosoma mansoni hypothetical protein 0.0094 0.2128 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0405
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0009 0.0031
Onchocerca volvulus Putative transporter 0.0013 0.0042 0.0123
Onchocerca volvulus 0.0013 0.0042 0.0123
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0009 0.0031
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0113 0.1383
Plasmodium vivax proline--tRNA ligase, putative 0.0033 0.055 0.051
Plasmodium falciparum calcium-dependent protein kinase 4 0.0029 0.0445 0.0404
Plasmodium falciparum protein kinase 7 0.0266 0.6557 0.6542
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Plasmodium falciparum calcium-dependent protein kinase 1 0.0029 0.0445 0.0404
Onchocerca volvulus 0.0013 0.0042 0.0123
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Brugia malayi Sugar transporter family protein 0.0013 0.0042 0.0123
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0013 0.0042 0.0159
Plasmodium falciparum lysine--tRNA ligase 0.0021 0.0243 0.0201
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Leishmania major glucose transporter, lmgt1 0.0029 0.0454 0.8107
Brugia malayi hypothetical protein 0.0013 0.0042 0.0123
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0029 0.0445 0.0617
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0029 0.0444 0.1585
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0028 0.0429 0.1984
Onchocerca volvulus 0.0013 0.0042 0.0123
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0028 0.0429 0.1984
Loa Loa (eye worm) hypothetical protein 0.0029 0.0444 0.1612
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0021 0.0243 0.395
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Onchocerca volvulus 0.0013 0.0042 0.0123
Brugia malayi major facilitator superfamily protein 0.0013 0.0042 0.0123
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Onchocerca volvulus 0.0013 0.0042 0.0123
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Brugia malayi major facilitator superfamily protein 0.0013 0.0042 0.0123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0405
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0013 0.0042 0.5
Giardia lamblia Prolyl-tRNA synthetase 0.0028 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0021 0.0243 0.3046
Onchocerca volvulus Huntingtin homolog 0.0119 0.2756 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0009 0.0031
Chlamydia trachomatis lysine--tRNA ligase 0.0021 0.0243 0.5
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0029 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Schistosoma mansoni glucose transport protein 0.0094 0.2128 1
Onchocerca volvulus 0.0013 0.0042 0.0123
Plasmodium vivax CDK-related protein kinase 6, putative 0.04 1 1
Echinococcus granulosus solute carrier family 22 0.0013 0.0042 0.0159
Plasmodium falciparum hexose transporter 0.0094 0.2128 0.2094
Echinococcus granulosus solute carrier family 22 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0454 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Onchocerca volvulus 0.0013 0.0042 0.0123
Trypanosoma brucei glucose transporter 1E 0.0029 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Leishmania major glucose transporter/membrane transporter D2, putative 0.0029 0.0454 0.8107
Leishmania major glucose transporter, lmgt3 0.0029 0.0454 0.8107
Brugia malayi Sugar transporter family protein 0.0094 0.2128 0.7712
Onchocerca volvulus 0.0013 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Echinococcus granulosus Sugar transporter ERD6 protein 0.0013 0.0042 0.0159
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0009 0.0031
Loa Loa (eye worm) major facilitator superfamily transporter 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0405
Plasmodium falciparum mitogen-activated protein kinase 2 0.0152 0.3622 0.3595
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0009 0.0031
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0018 0.0176 0.0641
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0029 0.0445 0.0617
Onchocerca volvulus Huntingtin homolog 0.0119 0.2756 1
Plasmodium falciparum proline--tRNA ligase 0.0033 0.055 0.051
Onchocerca volvulus 0.0013 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0013 0.0042 0.0159
Echinococcus multilocularis calcium dependent protein kinase 0.0027 0.0398 0.1839
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0028 0.0429 0.1984
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0095 0.0313
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0028 0.0429 0.1557
Schistosoma mansoni glucose transport protein 0.0094 0.2128 1
Plasmodium vivax hexose transporter 0.0094 0.2128 0.2094
Trypanosoma cruzi hexose transporter 0.0029 0.0454 0.8107
Brugia malayi Cam kinase protein 1 0.0029 0.0444 0.1585
Entamoeba histolytica protein kinase, putative 0.0029 0.0444 1
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.2128 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Onchocerca volvulus 0.0013 0.0042 0.0123
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0018 0.0161 1
Schistosoma mansoni sugar transporter 0.0013 0.0042 0.0159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0944 0.3426
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0454 0.1973
Echinococcus granulosus General substrate transporter 0.0081 0.1787 0.839
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0028 0.0429 0.153
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0029 0.0445 0.0617
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0454 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0454 0.8107
Plasmodium vivax calcium-dependent protein kinase, putative 0.0029 0.0445 0.0404
Schistosoma mansoni protein kinase 0.0029 0.0444 0.2055
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0551 0.1974
Toxoplasma gondii protein kinase, putative 0.0266 0.6557 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2756 1
Trypanosoma brucei glucose transporter, putative 0.0029 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0033 0.055 1
Brugia malayi hypothetical protein 0.0013 0.0042 0.0123
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0033 0.055 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0029 0.0444 0.1612
Schistosoma mansoni glucose transport protein 0.0094 0.2128 1
Brugia malayi hypothetical protein 0.0119 0.2756 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Giardia lamblia Lysyl-tRNA synthetase 0.0021 0.0243 0.5182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0944 0.3405
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Onchocerca volvulus 0.0013 0.0042 0.0123
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0028 0.0429 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0454 0.1973
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0009 0.0031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0095 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0454 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0454 0.1973
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0021 0.0243 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0454 0.1973
Brugia malayi Major Facilitator Superfamily protein 0.0013 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0018 0.0161 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0028 0.0429 1
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0405
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Schistosoma mansoni sugar transporter 0.0013 0.0042 0.0159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0454 0.1973
Trypanosoma brucei glucose transporter 2A 0.0029 0.0454 0.8107
Toxoplasma gondii facilitative glucose transporter GT1 0.0094 0.2128 0.3201
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0454 0.1973
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0029 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Toxoplasma gondii lysine-tRNA ligase 0.0021 0.0243 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0293 0.1062
Schistosoma mansoni lysyl-tRNA synthetase 0.0021 0.0243 0.1105
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0444 0.2055
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0454 0.8107
Echinococcus multilocularis synaptic vesicle 2 protein 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0028 0.0429 0.1557
Echinococcus granulosus lysyl tRNA synthetase 0.0021 0.0243 0.1105
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0029 0.0444 0.1612
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0094 0.2128 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0029 0.0454 0.8107
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0095 0.0313
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0405
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Onchocerca volvulus 0.0013 0.0042 0.0123
Plasmodium falciparum calcium-dependent protein kinase 5 0.0029 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0029 0.0445 0.0404
Loa Loa (eye worm) major facilitator superfamily transporter 0.0013 0.0042 0.0154
Brugia malayi hypothetical protein 0.0013 0.0042 0.0123
Schistosoma mansoni hypothetical protein 0.0033 0.0551 0.2559
Echinococcus multilocularis solute carrier family 22 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0405
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0454 0.1973
Brugia malayi Major Facilitator Superfamily protein 0.0013 0.0042 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0944 0.3405
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Brugia malayi lysyl-tRNA synthetase 0.0021 0.0243 0.0852
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0009 0.0031
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0243 0.0961
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Entamoeba histolytica protein kinase, putative 0.0029 0.0444 1
Trichomonas vaginalis CAMK family protein kinase 0.0029 0.0444 0.1927
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0028 0.0429 0.1984
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0009 0.0031
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0028 0.0429 0.153
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0033 0.055 1
Brugia malayi Sugar transporter family protein 0.0013 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0028 0.0429 0.9253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0029 0.0444 0.2055
Echinococcus multilocularis solute carrier family 22 0.0013 0.0042 0.0159
Schistosoma mansoni protein kinase 0.0029 0.0444 0.2055
Loa Loa (eye worm) sugar transporter 0.0094 0.2128 0.772
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0033 0.055 1
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0405
Schistosoma mansoni lysyl-tRNA synthetase 0.0021 0.0243 0.1105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0029 0.0444 0.7919
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Schistosoma mansoni protein kinase 0.0029 0.0444 0.2055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Onchocerca volvulus 0.0013 0.0042 0.0123
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0009 0.0031
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0021 0.0243 1
Schistosoma mansoni glucose transporter 0.0013 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031
Echinococcus multilocularis solute carrier family 22 0.0013 0.0042 0.0159
Plasmodium falciparum calcium-dependent protein kinase 2 0.0029 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0031

Activities

Activity type Activity value Assay description Source Reference
EC20 (functional) > 100 uM Dose required to produce 20% increase in effective refractory period in male ferret. ChEMBL. 11133100
Tension (functional) = -53 % Peak isometric tension during the basic stimulus trains (S1) during control and compound induced tension, expressed as percent control. ChEMBL. 11133100

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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