Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.7638 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0276 | 0.727 | 1 |
Onchocerca volvulus | 0.0126 | 0.2178 | 1 | |
Brugia malayi | Endochitinase | 0.0089 | 0.0929 | 0.0847 |
Echinococcus granulosus | dual specificity | 0.0276 | 0.727 | 0.7341 |
Brugia malayi | hypothetical protein | 0.0354 | 0.9902 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0064 | 0.0098 | 0.0099 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.7638 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0276 | 0.727 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0276 | 0.727 | 0.7243 |
Plasmodium vivax | hypothetical protein, conserved | 0.0126 | 0.2178 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0354 | 0.9902 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.01 | 0.1317 | 0.1812 |
Entamoeba histolytica | chitinase, putative | 0.0079 | 0.0606 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.2178 | 0.2101 |
Brugia malayi | Protein kinase domain containing protein | 0.01 | 0.1317 | 0.1243 |
Onchocerca volvulus | 0.0126 | 0.2178 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0354 | 0.9902 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.01 | 0.1317 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0212 | 0.0115 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0354 | 0.9902 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0276 | 0.727 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0354 | 0.9902 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0276 | 0.727 | 0.7315 |
Echinococcus multilocularis | dual specificity | 0.01 | 0.1317 | 0.133 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0276 | 0.727 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0276 | 0.727 | 0.7341 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0276 | 0.727 | 1 |
Echinococcus multilocularis | dual specificity | 0.0276 | 0.727 | 0.7341 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1219 | 0.1132 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0064 | 0.0098 | 0.0099 |
Onchocerca volvulus | Putative endochitinase | 0.0089 | 0.0929 | 0.2052 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0079 | 0.0606 | 0.0513 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0098 | 0.0099 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0126 | 0.2178 | 0.2199 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.01 | 0.1317 | 0.17 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0276 | 0.727 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0089 | 0.0929 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1219 | 0.1132 |
Brugia malayi | endochitinase | 0.0079 | 0.0606 | 0.0518 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0276 | 0.727 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0064 | 0.0098 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.2178 | 0.2199 |
Loa Loa (eye worm) | haspin protein kinase | 0.0354 | 0.9902 | 0.9901 |
Echinococcus granulosus | dual specificity | 0.0276 | 0.727 | 0.7341 |
Entamoeba histolytica | hypothetical protein | 0.01 | 0.1317 | 0.1812 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0077 | 0.0535 | 0.0441 |
Loa Loa (eye worm) | haspin protein kinase | 0.0354 | 0.9902 | 0.9901 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0064 | 0.0098 | 0.0135 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0354 | 0.9902 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.01 | 0.1317 | 0.17 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0276 | 0.727 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0276 | 0.727 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 0.1317 | 0.1812 |
Brugia malayi | GSG2 | 0.0354 | 0.9902 | 1 |
Echinococcus multilocularis | dual specificity | 0.0276 | 0.727 | 0.7341 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0276 | 0.727 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0079 | 0.0606 | 0.0513 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0126 | 0.2178 | 0.2121 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.9902 | 1 |
Echinococcus granulosus | dual specificity | 0.0276 | 0.727 | 0.7341 |
Leishmania major | chitinase | 0.0079 | 0.0606 | 0.0709 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0064 | 0.0098 | 0.0099 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.01 | 0.1317 | 0.1231 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0098 | 0.0099 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0276 | 0.727 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0276 | 0.727 | 1 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0064 | 0.0098 | 0.0099 |
Plasmodium falciparum | conserved protein, unknown function | 0.0126 | 0.2178 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 0.1317 | 0.1812 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0126 | 0.2178 | 0.2199 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0267 | 0.6954 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0064 | 0.0098 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.2178 | 0.2101 |
Echinococcus multilocularis | dual specificity | 0.0276 | 0.727 | 0.7341 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0064 | 0.0098 | 0.0099 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.01 | 0.1317 | 0.17 |
Echinococcus granulosus | dual specificity | 0.01 | 0.1317 | 0.133 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0064 | 0.0098 | 0.0099 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0276 | 0.727 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0089 | 0.0929 | 0.2052 |
Schistosoma mansoni | serine/threonine kinase | 0.0064 | 0.0098 | 0.0099 |
Brugia malayi | endochitinase | 0.0089 | 0.0929 | 0.0847 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.1317 | 0.133 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.